Le Moal M A, Truffa-Bachi P
Unité d'immunophysiologie moléculaire, Institut Pasteur, Paris, France.
Biochem Cell Biol. 1989 Sep;67(9):490-4. doi: 10.1139/o89-079.
The effects of cyclosporin A on the generation and revelation of B memory cells by thymus-independent (TI) antigens was investigated. A class 1 (TNP-LPS) and a class 2 (TNP-Ficoll) TI antigens were used for priming an elicitation. Evidence is presented that cyclosporin A does not interfere with the generation of hapten-specific (TNP) B memory cells by TNP-LPS or DNP-Ficoll. Cyclosporin A does not affect the revelation of B memory cells by TNP-LPS, but inhibits their revelation by TNP-Ficoll. These findings are discussed in terms of two distinct B cell lineages leading to antibody-forming cells and memory cells precursors, and in terms of heterogeneity of B memory cells.
研究了环孢素A对非胸腺依赖性（TI）抗原诱导和激活B记忆细胞的影响。使用1类（TNP-LPS）和2类（TNP-菲可）TI抗原进行初次免疫和激发。有证据表明，环孢素A不干扰TNP-LPS或DNP-菲可诱导产生半抗原特异性（TNP）B记忆细胞。环孢素A不影响TNP-LPS激活B记忆细胞，但抑制TNP-菲可对其的激活。从导致抗体形成细胞和记忆细胞前体的两个不同B细胞谱系以及B记忆细胞的异质性方面对这些发现进行了讨论。
