Shidani B, Colle J H, Motta I, Truffa-Bachi P
Eur J Immunol. 1983 May;13(5):359-63. doi: 10.1002/eji.1830130503.
The effect of cyclosporin A on the induction and activation of B memory cells by thymus-independent (TI) antigens was investigated. Studies were carried out in C57BL/6 mice, a strain in which TI.1 trinitrophenyl-lipopolysaccharide (TNP-LPS) and TI.2 dinitrophenyl-(DNP)-Ficoll antigens can elicit a secondary response. Evidence is presented that cyclosporin A does not adversely affect the primary or secondary response to TNP-LPS. In contrast, this fungal metabolite prevents the triggering of virgin B lymphocytes and TNP-LPS-induced memory cells by DNP-Ficoll. Cyclosporin A does not interfere with the generation of hapten-specific B memory cells by TNP-LPS or DNP-Ficoll. These findings are discussed in terms of B cell lineages leading to antibody-forming cell precursors and memory cells.
研究了环孢素A对非胸腺依赖性（TI）抗原诱导和激活B记忆细胞的影响。实验在C57BL/6小鼠中进行，该品系中TI.1三硝基苯基脂多糖（TNP-LPS）和TI.2二硝基苯基-（DNP）-Ficoll抗原可引发二次反应。有证据表明，环孢素A对TNP-LPS的初次或二次反应没有不利影响。相比之下，这种真菌代谢产物可阻止DNP-Ficoll触发未成熟B淋巴细胞和TNP-LPS诱导的记忆细胞。环孢素A不干扰TNP-LPS或DNP-Ficoll产生半抗原特异性B记忆细胞。根据导致抗体形成细胞前体和记忆细胞的B细胞谱系对这些发现进行了讨论。
