Podbielski F J, Bridenstine R T, Vesselinovitch D, Wissler R W
Program of Arts and Sciences Basic to Human Biology and Medicine, University of Chicago, Ill.
Appl Pathol. 1989;7(4):241-8.
Platelet factor 4 (PF 4), the low molecular weight polypeptide stored in the alpha granule, has been shown to be released from platelets during the process of activation. To examine the effects of known atherogenic food fats on platelet activation, as manifested in circulating PF 4 concentrations, groups of rhesus monkeys were fed diets enriched with varying quantities of different food fats. Plasma PF 4 levels were measured at set intervals during the experimental period. Platelet counts were performed and PF 4 values assayed using the radioligand binding technique. Animals given coconut-oil-enriched diets showed the greatest increase in PF 4 levels; while those fed corn, peanut and soybean-oil-containing rations showed small insignificant fluctuations of plasma PF 4 values. In this study the coconut oil effect on plasma PF 4 values increased with time; diluting the coconut oil with increasing quantities of corn oil led to progressive decreases in these values. These data indicate an increased incidence of platelet activation in animals fed coconut-oil-enriched diets, and suggest that corn oil counteracts this thromboactive effect of coconut oil.
血小板因子4（PF 4）是一种储存在α颗粒中的低分子量多肽，已证实在激活过程中可从血小板中释放出来。为了研究已知的致动脉粥样硬化食物脂肪对血小板激活的影响（表现为循环中PF 4浓度），给几组恒河猴喂食富含不同数量不同食物脂肪的饮食。在实验期间按设定的间隔测量血浆PF 4水平。进行血小板计数，并使用放射性配体结合技术测定PF 4值。喂食富含椰子油饮食的动物PF 4水平升高幅度最大；而喂食含玉米油、花生油和大豆油日粮的动物血浆PF 4值仅有微小的无显著意义的波动。在本研究中，椰子油对血浆PF 4值的影响随时间增加；用越来越多的玉米油稀释椰子油会导致这些值逐渐降低。这些数据表明，喂食富含椰子油饮食的动物血小板激活发生率增加，并提示玉米油可抵消椰子油的这种促血栓形成作用。
