Mangas-Sanchez Juan, France Scott P, Montgomery Sarah L, Aleku Godwin A, Man Henry, Sharma Mahima, Ramsden Jeremy I, Grogan Gideon, Turner Nicholas J
School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK.
York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
Curr Opin Chem Biol. 2017 Apr;37:19-25. doi: 10.1016/j.cbpa.2016.11.022. Epub 2016 Dec 27.
Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.
亚胺还原酶（IREDs）已成为用于光学活性胺不对称合成的一组有价值的新型生物催化剂。生物信息学工具和可搜索数据库的发展使得人们能够鉴定出多种新型IRED生物催化剂，这些催化剂已得到表征并应用于不同的合成过程。本综述描述了IREDs在结构和机理方面的最新进展，以及这些酶的合成应用，并指出了该领域当前和未来面临的挑战。
