Burr D B, Schaffler M B, Yang K H, Wu D D, Lukoschek M, Kandzari D, Sivaneri N, Blaha J D, Radin E L
Department of Anatomy, West Virginia University Health Sciences, Morgantown 26506.
Bone. 1989;10(3):215-21. doi: 10.1016/8756-3282(89)90056-2.
This study defines the alteration in bone tissue kinetics responsible for the "adaptive remodeling" response to altered strain environments. Adult beagle dogs were separated into three experimental groups: ulnar osteotomy, ulnar osteotomy with fracture fixation plate spanning the gap and sham surgery. Four sets of double fluorochrome labels were administered. Prior to sacrifice at 1, 3, and 6 months, strains were measured through rosette strain gages on the cranial and caudal surfaces of the intact radius. Histomorphometric analysis indicated that the increased bone mass in response to elevated strain results from increased activation frequency of modeling with more sites undergoing formation processes than resorption processes on periosteal and endocortical surfaces. Increased remodeling activation did not lead to increased bone mass. There was no evidence that elevated strain changes the individual vigor of osteoclasts or osteoblasts, or that the sigma period was altered by elevated strain.
本研究确定了骨组织动力学的改变，这种改变是对应变环境改变的“适应性重塑”反应的原因。成年比格犬被分为三个实验组：尺骨截骨术组、用跨越间隙的骨折固定板进行尺骨截骨术组和假手术组。给予四组双荧光色素标记。在1、3和6个月处死前，通过完整桡骨颅侧和尾侧表面的应变片测量应变。组织形态计量学分析表明，对应变升高的反应中骨量增加是由于建模激活频率增加，在骨膜和骨内膜表面，经历形成过程的部位比吸收过程的部位更多。重塑激活增加并未导致骨量增加。没有证据表明应变升高会改变破骨细胞或成骨细胞的个体活力，也没有证据表明应变升高会改变西格玛期。
