Burr D B, Schaffler M B, Yang K H, Lukoschek M, Sivaneri N, Blaha J D, Radin E L
Department of Anatomy, West Virginia University, Morgantown.
Bone. 1989;10(3):223-33. doi: 10.1016/8756-3282(89)90057-4.
Studies demonstrate that geometric changes in bone architecture in response to altered mechanical strain occur through the formation of woven bone. The goal of this study was to test the hypothesis that these changes are partly the result of surgical manipulation rather than a true adaptive response to altered strain. Beagle dogs were subjected to either an ulnar osteotomy, an osteotomy with plate fixation, or sham operation. Strains on the radius were measured just prior to sacrifice 1, 3 or 6 months after surgery. Our results support the idea that woven bone can be a normal response to an abnormal strain environment if the mechanical challenge is intense enough; that elevated mechanical strains can cause the endocortical bone envelope to revert to a state of net formation; and that "adaptive remodeling" in adults in response to a change in mechanical strain may be a special case of modeling in which resorption is not required prior to formation at a particular skeletal site.
研究表明，骨结构的几何变化是对机械应变改变的响应，通过编织骨的形成而发生。本研究的目的是检验这样一种假设，即这些变化部分是手术操作的结果，而非对应变改变的真正适应性反应。对比格犬进行尺骨截骨术、带钢板固定的截骨术或假手术。在术后1、3或6个月处死前测量桡骨上的应变。我们的结果支持以下观点：如果机械刺激足够强烈，编织骨可以是对异常应变环境的正常反应；机械应变升高可导致骨内膜骨壳恢复到净形成状态；并且成年人对机械应变变化的“适应性重塑”可能是一种特殊的塑形情况，即在特定骨骼部位形成之前不需要吸收。
