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用于重建脑可塑性关键时期的牙基质生物标志物。

Tooth-Matrix Biomarkers to Reconstruct Critical Periods of Brain Plasticity.

作者信息

Morishita Hirofumi, Arora Manish

机构信息

Department of Psychiatry, Neuroscience, and Ophthalmology, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Division of Environmental Health, Department of Environmental Medicine and Public Health, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

出版信息

Trends Neurosci. 2017 Jan;40(1):1-3. doi: 10.1016/j.tins.2016.11.003. Epub 2016 Dec 27.

Abstract

Developmental brain plasticity involves complex, time-dependent dynamic molecular interactions that cannot be observed directly in humans. We propose that the shared evolutionary homology of teeth and the neurosensory system, and the archival nature of dentine microstructure, allows the development of 'biologic hard drives' that can characterize perinatal temporal dynamics in neuroplasticity.

摘要

发育中的大脑可塑性涉及复杂的、时间依赖性的动态分子相互作用,而这些相互作用无法在人类中直接观察到。我们提出,牙齿与神经感觉系统的共同进化同源性以及牙本质微观结构的存档性质,使得“生物硬盘”得以发展,这种“生物硬盘”能够表征神经可塑性中的围产期时间动态。

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Genetic control of experience-dependent plasticity in the visual cortex.视觉皮层中经验依赖性可塑性的遗传控制。
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