Morishita Hirofumi, Arora Manish
Department of Psychiatry, Neuroscience, and Ophthalmology, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Environmental Health, Department of Environmental Medicine and Public Health, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Trends Neurosci. 2017 Jan;40(1):1-3. doi: 10.1016/j.tins.2016.11.003. Epub 2016 Dec 27.
Developmental brain plasticity involves complex, time-dependent dynamic molecular interactions that cannot be observed directly in humans. We propose that the shared evolutionary homology of teeth and the neurosensory system, and the archival nature of dentine microstructure, allows the development of 'biologic hard drives' that can characterize perinatal temporal dynamics in neuroplasticity.
发育中的大脑可塑性涉及复杂的、时间依赖性的动态分子相互作用,而这些相互作用无法在人类中直接观察到。我们提出,牙齿与神经感觉系统的共同进化同源性以及牙本质微观结构的存档性质,使得“生物硬盘”得以发展,这种“生物硬盘”能够表征神经可塑性中的围产期时间动态。