Merced-Nieves Francheska M, Arora Manish, Wright Robert O, Curtin Paul
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Curr Opin Toxicol. 2021 Jun;26:28-32. doi: 10.1016/j.cotox.2021.03.005. Epub 2021 Apr 2.
Children are constantly exposed to a wide range of environmental factors including essential and non-essential metals. In recent years, the paradigm has emerged to foster the examination of combined effects that emerge from exposures to multiple elements. In this review, we summarized recent literature studying the relationship between prenatal and childhood metal mixtures with neurodevelopmental outcomes. Our review highlights two basic principles to emerge from this approach. First, recent findings emphasize that the effect of a given exposure is contextual and may be dependent on past or concurrent metal exposures. Second, the timing of exposures is equally critical to the mixture composition in determining neurodevelopmental effects. Our discussion emphasizes how these principles may apply to future exposure-related neurodevelopmental studies.
儿童不断接触各种环境因素，包括必需金属和非必需金属。近年来，出现了一种模式，以促进对多种元素暴露所产生的综合影响的研究。在本综述中，我们总结了近期研究产前和儿童期金属混合物与神经发育结果之间关系的文献。我们的综述强调了从这种方法中得出的两个基本原则。首先，近期研究结果强调，给定暴露的影响是情境性的，可能取决于过去或同时发生的金属暴露。其次，暴露时间对于确定神经发育影响的混合物组成同样至关重要。我们的讨论强调了这些原则如何应用于未来与暴露相关的神经发育研究。
