Maffini Enrico, Festuccia Moreno, Brunello Lucia, Boccadoro Mario, Giaccone Luisa, Bruno Benedetto
Department of Oncology, AOU Città della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Department of Oncology, AOU Città della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Biol Blood Marrow Transplant. 2017 Mar;23(3):388-397. doi: 10.1016/j.bbmt.2016.12.632. Epub 2016 Dec 27.
Neurologic complications after hematopoietic stem cell transplantation are frequently life-threatening, and their clinical management can be highly challenging. A wide spectrum of causative factors-including drug-related toxicities; infections sustained by virus, bacteria, or invasive molds; metabolic encephalopathy; cerebrovascular disorders; immune-mediated disorders; and disease recurrence-may lead to potentially lethal complications. Moreover, given that some neurologic complications are not uncommonly diagnosed post mortem, their overall incidence is likely to be underestimated. Their prompt recognition and timely treatment are of paramount importance to reduce the risk for transplantation-related death.
造血干细胞移植后的神经系统并发症常常危及生命，其临床管理极具挑战性。多种致病因素——包括药物相关毒性；病毒、细菌或侵袭性霉菌引起的感染；代谢性脑病；脑血管疾病；免疫介导的疾病；以及疾病复发——都可能导致潜在的致命并发症。此外，鉴于一些神经系统并发症在尸检后并不罕见，它们的总体发病率可能被低估。对其迅速识别和及时治疗对于降低移植相关死亡风险至关重要。
