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[单倍体造血干细胞移植后韦尼克脑病：3例报告及文献复习]

[Wernicke's encephalopathy after haploid hematopoietic stem cell transplantation: 3 cases report and literature review].

作者信息

Xiao Q Q, Yu X L, Song X C, Li W J, Deng L, Hou Y X, Zhou F

机构信息

School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, China Department of Hematology, The 960th Hospital of The People's Liberation Army (PLA) Joint Logistics Support Force, Jinan 250031, China.

Department of Hematology, The 960th Hospital of The People's Liberation Army (PLA) Joint Logistics Support Force, Jinan 250031, China.

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2024 Aug 14;45(8):781-784. doi: 10.3760/cma.j.cn121090-20231214-00309.

DOI:10.3760/cma.j.cn121090-20231214-00309
PMID:39307727
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11535564/
Abstract

Case 1: A 27-year-old female with ALK-positive anaplastic large cell lymphoma/leukemia; Case 2: A 27-year-old male with acute myeloid leukemia; Case 3: A 56-year-old male with myelodysplastic syndrome. These three patients underwent haploid hematopoietic stem cell transplantation and experienced severe oral mucosal inflammation, nausea, vomiting, diarrhea, and other symptoms over a long period, which significantly restricted eating. Neurological and psychiatric symptoms appeared at 50, 38, and 50 days following transplantation, respectively. The diagnosis of Wernicke encephalopathy was made by head magnetic resonance imaging, whereas the condition improved significantly after intravenous infusion of vitamin B(1).

摘要

病例1：一名27岁的ALK阳性间变性大细胞淋巴瘤/白血病女性；病例2：一名27岁的急性髓系白血病男性；病例3：一名56岁的骨髓增生异常综合征男性。这三名患者接受了单倍体造血干细胞移植，长期出现严重的口腔黏膜炎症、恶心、呕吐、腹泻等症状，严重限制了进食。分别在移植后50天、38天和50天出现神经和精神症状。通过头部磁共振成像诊断为韦尼克脑病，静脉输注维生素B1后病情明显改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5585/11535564/686d532e4f95/cjh-45-08-781-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5585/11535564/550127720e8f/cjh-45-08-781-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5585/11535564/3edb421170c0/cjh-45-08-781-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5585/11535564/686d532e4f95/cjh-45-08-781-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5585/11535564/550127720e8f/cjh-45-08-781-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5585/11535564/3edb421170c0/cjh-45-08-781-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5585/11535564/686d532e4f95/cjh-45-08-781-g003.jpg

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本文引用的文献

1
Noninfectious Neurologic Complications after Allogeneic Hematopoietic Stem Cell Transplantation.异基因造血干细胞移植后的非感染性神经系统并发症。
Biol Blood Marrow Transplant. 2019 Sep;25(9):1818-1824. doi: 10.1016/j.bbmt.2019.05.024. Epub 2019 May 24.
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Wernicke's encephalopathy following allogeneic hematopoietic stem cell transplantation.异基因造血干细胞移植后韦尼克脑病
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Oncology. 2009;76(1):10-8. doi: 10.1159/000174951. Epub 2008 Nov 19.
8
Neurological complications of hematopoietic stem cell transplantation (HSCT): a retrospective study in a HSCT center in Brazil.造血干细胞移植（HSCT）的神经并发症：巴西一家HSCT中心的回顾性研究。
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Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management.韦尼克脑病：新的临床情况及诊断与治疗的最新进展
Lancet Neurol. 2007 May;6(5):442-55. doi: 10.1016/S1474-4422(07)70104-7.
10
The Royal College of Physicians report on alcohol: guidelines for managing Wernicke's encephalopathy in the accident and Emergency Department.皇家内科医师学院关于酒精的报告：急诊科韦尼克脑病管理指南。
Alcohol Alcohol. 2002 Nov-Dec;37(6):513-21. doi: 10.1093/alcalc/37.6.513.