PBIT：用于识别传染病药物靶点的管道构建器。
PBIT: Pipeline Builder for Identification of drug Targets for infectious diseases.
作者信息
Shende Gauri, Haldankar Harshala, Barai Ram Shankar, Bharmal Mohammed Husain, Shetty Vinit, Idicula-Thomas Susan
机构信息
ICMR Biomedical Informatics Center, National Institute for Research in Reproductive Health, Mumbai, India.
出版信息
Bioinformatics. 2017 Mar 15;33(6):929-931. doi: 10.1093/bioinformatics/btw760.
SUMMARY
PBIT (Pipeline Builder for Identification of drug Targets) is an online webserver that has been developed for screening of microbial proteomes for critical features of human drug targets such as being non-homologous to human proteome as well as the human gut microbiota, essential for the pathogen's survival, participation in pathogen-specific pathways etc. The tool has been validated by analyzing 57 putative targets of Candida albicans documented in literature. PBIT integrates various in silico approaches known for drug target identification and will facilitate high-throughput prediction of drug targets for infectious diseases, including multi-pathogenic infections.
AVAILABILITY AND IMPLEMENTATION
PBIT is freely accessible at http://www.pbit.bicnirrh.res.in/ .
CONTACT
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
摘要
PBIT（用于识别药物靶点的管道构建器）是一个在线网络服务器，它被开发用于筛选微生物蛋白质组，以寻找人类药物靶点的关键特征，如与人类蛋白质组以及人类肠道微生物群非同源、对病原体生存至关重要、参与病原体特异性途径等。该工具已通过分析文献中记录的白色念珠菌的57个假定靶点进行了验证。PBIT整合了各种已知的用于药物靶点识别的计算机方法，并将促进对包括多重病原体感染在内的传染病药物靶点的高通量预测。
可用性和实现方式
可通过http://www.pbit.bicnirrh.res.in/免费访问PBIT。
联系方式
补充信息
补充数据可在《生物信息学》在线获取。
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