Fukao Akira, Fujiwara Toshinobu
J Biochem. 2017 Apr 1;161(4):309-314. doi: 10.1093/jb/mvw086.
In mammals, spatiotemporal control of protein synthesis plays a key role in the post-transcriptional regulation of gene expression during cell proliferation, development and differentiation and RNA-binding proteins (RBPs) and microRNAs (miRNAs) are required for this phenomenon. RBPs and miRNAs control the levels of mRNA protein products by regulating mRNA stability and translation. Recent studies have shown that RBPs and miRNAs simultaneously regulate mRNA stability and translation, and that the differential functions of RBPs and miRNAs are dependent on their interaction partners. Here, we summarize the coupled- and uncoupled mechanisms by which trans-acting factors regulate mRNA stability and translation.
在哺乳动物中，蛋白质合成的时空控制在细胞增殖、发育和分化过程中基因表达的转录后调控中起着关键作用，而RNA结合蛋白（RBPs）和微小RNA（miRNAs）参与这一过程。RBPs和miRNAs通过调节mRNA的稳定性和翻译来控制mRNA蛋白质产物的水平。最近的研究表明，RBPs和miRNAs同时调节mRNA的稳定性和翻译，且RBPs和miRNAs的不同功能取决于它们的相互作用伙伴。在此，我们总结了反式作用因子调节mRNA稳定性和翻译的偶联和非偶联机制。
