Famà Valeria, Coscujuela Tarrero Lucia, Albanese Roberto, Calviello Lorenzo, Biffo Stefano, Pelizzola Mattia, Furlan Mattia
Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan, Italy.
Department of Oncology and Emato-Oncology, University of Milan, Milan, Italy.
RNA Biol. 2025 Dec;22(1):1-12. doi: 10.1080/15476286.2025.2483001. Epub 2025 Mar 24.
Gene expression involves a series of consequential processes, beginning with mRNA synthesis and culminating in translation. Traditionally studied as a linear sequence of events, recent findings challenge this perspective, revealing coupling mechanisms that coordinate key steps of gene expression, even when spatially and temporally distant. In this review, we focus on translation, the final stage of gene expression, and examine its coupling with key stages of mRNA metabolism: synthesis, processing, export, and decay. For each of these processes, we provide an overview of known instances of coupling with translation. Furthermore, we discuss the role of high-throughput technologies in uncovering these intricate interactions on a genome-wide scale. Finally, we highlight key challenges and propose future directions to advance our understanding of how coupling mechanisms orchestrate robust and adaptable gene expression programs.
基因表达涉及一系列连续的过程，始于mRNA合成并最终以翻译结束。传统上，基因表达被视为一系列线性事件，然而最近的研究结果对这一观点提出了挑战，揭示了即使在空间和时间上相隔较远的情况下，协调基因表达关键步骤的偶联机制。在这篇综述中，我们聚焦于基因表达的最后阶段——翻译，并研究其与mRNA代谢关键阶段的偶联：合成、加工、输出和降解。对于这些过程中的每一个，我们概述了已知的与翻译偶联的实例。此外，我们讨论了高通量技术在全基因组范围内揭示这些复杂相互作用中的作用。最后，我们强调了关键挑战，并提出了未来的研究方向，以推动我们对偶联机制如何协调稳健且适应性强的基因表达程序的理解。
