正常人体胃肠道黏膜中转化生长因子α和表皮生长因子水平
Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa.
作者信息
Cartlidge S A, Elder J B
机构信息
Academic Surgical Unit, School of Postgraduate Medicine, University of Keele, Hartshill, Stoke on Trent, UK.
出版信息
Br J Cancer. 1989 Nov;60(5):657-60. doi: 10.1038/bjc.1989.334.
Abstract
Acid soluble proteins from 23 samples of normal human gastrointestinal mucosa derived from four normal adult organ donors were extracted and subjected to specific radiommunoassays for transforming growth factor alpha (TGF alpha) and urogastrone epidermal growth factor (URO-EGF). All tissues were found to contain immunoreactive TGF alpha and levels ranged from 57 to 4,776 pg-1 wet weight of tissue. Although levels varied between tissue donors, the distribution of TGF alpha throughout the gastrointestinal tract appeared similar in all cases. URO-EGF levels were much lower (0-216 pg g-1 wet weight). TGF alpha levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels. URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient. Further studies in juveniles are indicated.
摘要
从4名正常成年器官捐赠者提供的23份正常人胃肠道黏膜样本中提取酸溶性蛋白，并对其进行转化生长因子α（TGFα）和尿抑胃素表皮生长因子（URO-EGF）的特异性放射免疫分析。结果发现，所有组织均含有免疫反应性TGFα，其水平范围为每克组织湿重57至4776皮克。尽管不同组织捐赠者的水平有所差异，但在所有病例中，TGFα在整个胃肠道的分布似乎相似。URO-EGF水平则低得多（每克组织湿重0至216皮克）。一名7岁女性捐赠者的胃肠道黏膜提取物中的TGFα水平较高，且观察到的分布与成人水平明显不同。在该患者的黏膜或黏膜下组织提取物中未检测到URO-EGF。表明需要对青少年进行进一步研究。
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