Liu Fang, Zhang Zhongguo, Zhang Yong, Chen Yue, Yang Xiaoyu, Li Jibin, Zhao Jiaxing
Large-Scale Data Analysis Center of Cancer Precision Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Dadong District, Shenyang 110042, Liaoning Province, P R China.
Department of Colorectal Cancer Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Dadong District, Shenyang 110042, Liaoning Province, P R China.
Oncotarget. 2017 Feb 7;8(6):9849-9857. doi: 10.18632/oncotarget.14219.
We investigated the association between single nucleotide polymorphisms (SNPs) in ACYP2, which has been associated with telomere length in several types of cancer, and the risk of CRC in a Chinese Han population. In a case-control study that included 247 cases and 300 healthy controls, 14 SNPs in ACYP2 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender. We determined that rs843711 and rs843706 were associated with an increased risk of CRC (rs843711: OR = 1.376, 95% CI = 1.082-1.749, p = 0.009; rs843706: OR = 1.361, 95% CI = 1.069-1.733, p = 0.012). Additionally, rs6713088, rs843645, rs843711, and rs843706 were associated with an increased risk of CRC under additive and recessive models (p < 0.05). Finally, the "TTCTCGCC" and "CG" haplotypes decreased the risk of CRC, while the "AG" haplotype increase the risk of CRC. The association between rs843711 and CRC remained significant after Bonferroni correction for multiple comparisons (p ≤ 0.00036). Our data shed new light on the associations between genetic variants in the ACYP2 gene and CRC susceptibility in a Chinese Han population.
我们研究了ACYP2基因中的单核苷酸多态性（SNP）与中国汉族人群结直肠癌（CRC）风险之间的关联。ACYP2基因中的SNP已在几种类型的癌症中与端粒长度相关。在一项包含247例病例和300名健康对照的病例对照研究中，选择了ACYP2基因中的14个SNP，并使用Sequenom MassARRAY平台进行基因分型。在对年龄和性别进行校正后，使用无条件逻辑回归计算比值比（OR）和95%置信区间（CI）。我们确定rs843711和rs843706与CRC风险增加相关（rs843711：OR = 1.376，95%CI = 1.082 - 1.749，p = 0.009；rs843706：OR = 1.361，95%CI = 1.069 - 1.733，p = 0.012）。此外，在加性和隐性模型下，rs6713088、rs843645、rs843711和rs843706与CRC风险增加相关（p < 0.05）。最后，“TTCTCGCC”和“CG”单倍型降低了CRC风险，而“AG”单倍型增加了CRC风险。在进行多重比较的Bonferroni校正后，rs843711与CRC之间的关联仍然显著（p≤0.00036）。我们的数据为ACYP2基因中的遗传变异与中国汉族人群CRC易感性之间的关联提供了新的线索。
