胶质瘤中的外泌体通讯——综述

Exosomal communication in glioma - a review.

作者信息

Xu Hongsheng, Zhang Kezhong, Zong Hailiang, Shang Ming, Li Kai, He Xiaoguang

机构信息

Department of Neurosurgery, Central Hospital of Xuzhou, the Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China.

出版信息

J BUON. 2016 Nov-Dec;21(6):1368-1373.

PMID:28039693

Abstract

Cancer research has revealed the existence of cancer stem cells (CSCs). However, the influence of the surrounding stromal cells present in the microenvironment on CSCs is still poorly understood. The latest studies on gliomas suggested that the microenvironment of human gliomas contains both glioma stem cells (GSCs) and glioma associated (GA)-mesenchymal stem cells (MSCs; (GA-MSCs). Also, studies have suggested that nano- sized vesicles, termed exosomes, have been recently observed to contribute towards intercellular communication within the tumor niche. The present review article will highlight the current view of exosomal communication in gliomas.

摘要

癌症研究已揭示了癌症干细胞（CSCs）的存在。然而，人们对微环境中存在的周围基质细胞对癌症干细胞的影响仍知之甚少。关于胶质瘤的最新研究表明，人类胶质瘤的微环境中既包含胶质瘤干细胞（GSCs），也包含胶质瘤相关（GA）间充质干细胞（MSCs；即GA-MSCs）。此外，研究表明，最近观察到被称为外泌体的纳米级囊泡有助于肿瘤微环境中的细胞间通讯。本综述文章将重点介绍目前关于胶质瘤中外泌体通讯的观点。