Ziyaraa Maysoun A, Hamdan Farqad B, Mousa Liqaa R
Al-Imamian Al-Kadhimyian Medical City, Al-Kharkh Health Director, Baghdad, Iraq.
Department of Physiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
Taiwan J Obstet Gynecol. 2016 Dec;55(6):840-846. doi: 10.1016/j.tjog.2015.10.028.
This study aims to evaluate the role of kisspeptin-10 in preeclampsia and check for possible relationship between its severity and fetal growth well-being. Kisspeptin-10 may participate in implantation of the embryo, placenta formation, and maintenance of pregnancy.
One hundred women who completed 20 weeks of gestation with singleton pregnancies were divided into 60 peeclamptic and 40 normotensive control women. Kisspeptin-10 level estimation, and ultrasound and Doppler ultrasound studies for umbilical artery were performed during their second and third trimesters of pregnancy.
Plasma kisspeptin-10 level was lower in preeclamptic groups and inversely correlated with the severity of the disease. Its level directly correlated with estimated fetal weight in utero during both trimesters in patients with severe preeclampsia and with fetal birth weight in patients with mild preeclampsia, whereas an inverse correlation was observed in those with severe preeclampsia during their second trimester. Kisspeptin-10 level was directly related to the resistance index in the second trimester in patients with severe preeclampsia, while it inversely correlated with the systolic/diastolic ratio and resistance index in the third trimester in patients with mild preeclampsia.
Kisspeptin-10 level is useful in assessing the severity of preeclampsia and can be a novel marker downregulated in pregnant women with preeclampsia, especially in those who also developed impaired uteroplacental perfusion or intrauterine growth restriction.
本研究旨在评估 kisspeptin - 10 在子痫前期中的作用，并检查其严重程度与胎儿生长发育状况之间的可能关系。Kisspeptin - 10 可能参与胚胎着床、胎盘形成及维持妊娠。
100 例单胎妊娠且孕周达 20 周的孕妇被分为 60 例子痫前期患者和 40 例血压正常的对照组。在妊娠中期和晚期进行 kisspeptin - 10 水平测定以及脐动脉超声和多普勒超声检查。
子痫前期组血浆 kisspeptin - 10 水平较低，且与疾病严重程度呈负相关。在重度子痫前期患者的两个孕期中，其水平与子宫内估计胎儿体重直接相关，在轻度子痫前期患者中与胎儿出生体重直接相关，而在重度子痫前期患者的妊娠中期则观察到负相关。重度子痫前期患者在妊娠中期 kisspeptin - 10 水平与阻力指数直接相关，而轻度子痫前期患者在妊娠晚期其水平与收缩压/舒张压比值及阻力指数呈负相关。
Kisspeptin - 10 水平有助于评估子痫前期的严重程度，可作为子痫前期孕妇中下调的新型标志物，尤其是在那些同时出现子宫胎盘灌注受损或胎儿宫内生长受限的孕妇中。
