Stevenson K E, Hungerford J, Garner A
Moorfields Eye Hospital, London.
Br J Ophthalmol. 1989 Sep;73(9):739-42. doi: 10.1136/bjo.73.9.739.
Three cases of local extraocular extension of retinoblastoma following intraocular surgery via a transscleral approach have been seen in one centre during a 12-month period. This number represents a significant increase on the previous incidence of this serious complication, which may be related to more widespread use of vitrectomy techniques. Orbital and local lymph node recurrence of retinoblastoma have been associated with a very poor survival rate in the past, and steps must be taken to limit the chance of this happening should an intraocular surgical procedure be performed inadvertently on an eye containing a retinoblastoma. Early enucleation without implant is advised, and adjuvant orbital radiotherapy is strongly recommended, even when there is no histopathological evidence of local extraocular tumour spread.
在12个月期间，一个中心出现了3例经巩膜入路行眼内手术后视网膜母细胞瘤局部眼外扩展的病例。这一数字相较于该严重并发症的既往发生率有显著增加，这可能与玻璃体切割技术的更广泛应用有关。过去，视网膜母细胞瘤的眼眶和局部淋巴结复发与极低的生存率相关，因此若在无意中对患有视网膜母细胞瘤的眼睛进行眼内手术，必须采取措施限制此类情况发生的可能性。建议早期行无植入物眼球摘除术，即使在没有局部眼外肿瘤扩散的组织病理学证据时，也强烈推荐辅助性眼眶放疗。
