Mazidi Mohsen, Rezaie Peyman, Kengne A P, Stathopoulou Maria G, Azimi-Nezhad Mohsen, Siest Sophie
Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science (IC-UCAS), West Beichen Road, Chaoyang, China; Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, China.
Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S61-S64. doi: 10.1016/j.dsx.2016.12.004. Epub 2016 Dec 9.
Metabolic syndrome (MetS) is currently diagnosed by the co-presence of at least three of the five following abnormalities: abdominal obesity, dysglycaemia, elevated serum triglycerides, low high-density cholesterol (HDL) and finally elevated blood pressure. Metabolic syndrome increases the risk of developing cardiovascular disease and diabetes. This review is on the associations between MetS and vascular endothelial growth factor (VEGF). VEGF induces migration and proliferation of endothelial cells (ECs), increases vascular permeability and has a role in tumor growth, adipose tissue expansion, age-related macular degeneration and diabetic retinopathy. Circulating levels of VEGFs are elevated in obese individuals and it has also been suggested that VEGF is secreted from adipose tissues, especially from intra-abdominal adipose tissue. There is abundant evidence to support that poor glycemic control in diabetic patients is associated with increased plasma VEGF, which in turn may cause hypertension and several vascular complications in diabetic patients. Circulating VEGF levels are increased in children and young adults with type 1 diabetes mellitus and middle-aged diabetic patients with proliferative retinopathy. It has been revealed that plasma VEGF increases in patients with hyperlipidemia and may trigger the development of atherosclerosis. It can be concluded that there is a positive association between VEGF and components of MetS. Because of the importance of this relationship, more investigations are needed in this field.
代谢综合征（MetS）目前的诊断标准是同时出现以下五种异常中的至少三种：腹部肥胖、血糖异常、血清甘油三酯升高、高密度脂蛋白（HDL）降低以及血压升高。代谢综合征会增加患心血管疾病和糖尿病的风险。这篇综述聚焦于代谢综合征与血管内皮生长因子（VEGF）之间的关联。VEGF可诱导内皮细胞（ECs）迁移和增殖，增加血管通透性，并在肿瘤生长、脂肪组织扩张、年龄相关性黄斑变性和糖尿病视网膜病变中发挥作用。肥胖个体的循环VEGF水平升高，也有研究表明VEGF是由脂肪组织分泌的，尤其是腹内脂肪组织。有充分证据支持糖尿病患者血糖控制不佳与血浆VEGF升高有关，这反过来可能导致糖尿病患者出现高血压和多种血管并发症。1型糖尿病儿童和青年以及患有增殖性视网膜病变的中年糖尿病患者的循环VEGF水平升高。研究表明，高脂血症患者的血浆VEGF升高，可能引发动脉粥样硬化的发展。可以得出结论，VEGF与代谢综合征的各组分之间存在正相关。鉴于这种关系的重要性，该领域需要更多的研究。
