Biochemical studies of the iron cores and polypeptide shells of haemosiderin isolated from patients with primary or secondary haemochromatosis.
作者信息
Ward R J, O'Connell M J, Dickson D P, Reid N M, Wade V J, Mann S, Bomford A, Peters T J
机构信息
Department of Clinical Biochemistry, King's College School of Medicine and Dentistry, London, U.K.
出版信息
Biochim Biophys Acta. 1989 Oct 13;993(1):131-3. doi: 10.1016/0304-4165(89)90153-0.
PMID:2804120
Abstract
Haemosiderin isolated from different iron-loading syndromes, primary haemochromatosis (PHC) and secondary haemochromatosis (SHC) biochemically exhibited differences in both their iron core and peptide composition. The rate of release of iron from PHC haemosiderin to oxalate was 3-fold greater than that from SHC haemosiderin. The major peptides separated by SDS-PAGE showed a major band at Mr 20,000 for PHC haemosiderin and at Mr 15,000 for SHC haemosiderin.
摘要
Zotero 插件