Bano Giulia, Trevisan Caterina, Carraro Sara, Solmi Marco, Luchini Claudio, Stubbs Brendon, Manzato Enzo, Sergi Giuseppe, Veronese Nicola
Department of Medicine, Geriatrics Section, University of Padova, Italy.
Department of Neurosciences, University of Padova, Padova, Italy.
Maturitas. 2017 Feb;96:10-15. doi: 10.1016/j.maturitas.2016.11.006. Epub 2016 Nov 13.
Inflammatory cytokines have been shown to prompt muscle wasting, ultimately stimulating protein catabolism and suppressing muscle synthesis. However, the possible association between inflammatory parameters and sarcopenia is poorly understood. We therefore aimed to summarize the current evidence about this topic with a meta-analysis of studies reporting serum inflammatory parameters in patients with sarcopenia vs. people without sarcopenia (controls). An electronic PubMed and Scopus search through to 09/01/2016 and meta-analysis of cross-sectional studies comparing serum levels of inflammatory cytokines between patients with sarcopenia and controls was made, calculating random-effects standardized mean differences (SMDs) ±95% confidence intervals (CIs) as the effect size. Out of 1370 initial hits, 17 studies with a total of 11249 participants (3072 with sarcopenia and 8177 without) were meta-analyzed. Sarcopenic participants had significantly higher levels of CRP (SMD=0.51; 95%CI 0.26, 0.77; p<0.0001; I=96%) than controls. Conversely, serum IL6 levels were not significantly different (SMD=0.35; 95%CI: -0.19, 0.89; p=0.21; I=97%) in people with sarcopenia versus controls. Sarcopenic people did not have higher levels of TNF-α than controls (SMD=0.28; 95%CI -0.26, 0.83; p=0.31; I=97%). In conclusion, sarcopenia seems to be associated with elevated serum CRP levels; future longitudinal studies are needed to clarify this relationship.
炎症细胞因子已被证明可促使肌肉萎缩，最终刺激蛋白质分解代谢并抑制肌肉合成。然而，炎症参数与肌肉减少症之间的可能关联却鲜为人知。因此，我们旨在通过对报告肌肉减少症患者与非肌肉减少症患者（对照组）血清炎症参数的研究进行荟萃分析，总结有关该主题的现有证据。通过电子检索截至2016年1月9日的PubMed和Scopus数据库，并对比较肌肉减少症患者与对照组血清炎症细胞因子水平的横断面研究进行荟萃分析，计算随机效应标准化均数差（SMD）±95%置信区间（CI）作为效应量。在1370条初始检索结果中，对17项研究进行了荟萃分析，这些研究共有11249名参与者（3072名患有肌肉减少症，8177名未患）。与对照组相比，肌肉减少症患者的CRP水平显著更高（SMD = 0.51；95%CI 0.26，0.77；p < 0.0001；I² = 96%）。相反，肌肉减少症患者与对照组的血清IL6水平无显著差异（SMD = 0.35；95%CI：-0.19，0.89；p = 0.21；I² = 97%）。肌肉减少症患者的TNF-α水平并不高于对照组（SMD = 0.28；95%CI -0.26，0.83；p = 0.31；I² = 97%）。总之，肌肉减少症似乎与血清CRP水平升高有关；未来需要进行纵向研究以阐明这种关系。
