Lan Jinyan, An Chenwei, Ke Ye, Song Yuhong, Chen Chaohe, Tang Lixu
Martial Arts Academy, Wuhan Sports University, No. 461 Luoyu Rd., Hongshan District, Wuhan, 430079, Hubei, China.
BMC Public Health. 2025 Jul 19;25(1):2512. doi: 10.1186/s12889-025-23714-z.
The rising rates of obesity and Sarcopenia have attracted considerable academic interest. The Lipid Accumulation Product (LAP) serves as an indicator of abdominal obesity and cardiovascular risk; however, its association with Sarcopenia remains unexplored. The present study explores the relationship between LAP and Sarcopenia, with a focus on the intermediary function of diabetes in this association.
Cross-sectional data from 10,065 adults, collected through NHANES from 1999 to 2018, were analyzed. Multivariate logistic regression models were used to determine the odds ratio (OR) between LAP and Sarcopenia, and mediation analysis assessed diabetes's mediating effect on LAP-related Sarcopenia.
This study included a cohort of 10,065 participants aged 20 years and older, among whom 1,153 were diagnosed with Sarcopenia. In a fully adjusted model, the LAP exhibited a positive association with the prevalence of Sarcopenia (OR = 2.57, 95% CI = 1.46-4.50, P < 0.001). When LAP was transformed from a continuous to a categorical variable, higher LAP levels were associated with an increased prevalence of Sarcopenia compared to the lowest LAP quartile (OR = 4.70, 95% CI = 1.81-12.16, P < 0.001). The application of restricted cubic spline analysis revealed a curvilinear relationship between LAP and Sarcopenia prevalence, with a significant inflection point at LAP = 4. Subgroup and sensitivity analyses confirmed the consistent association between LAP and Sarcopenia. Additionally, diabetes mellitus was identified as a partial mediator in this association, accounting for a mediation proportion of 31.1%.
The study reveals a significant correlation between elevated levels of LAP and an increased prevalence of Sarcopenia, with diabetes identified as a mediating factor in this association. Further research is required to investigate the underlying mechanisms.
肥胖率和肌肉减少症的上升引起了学术界的广泛关注。脂质蓄积产物（LAP）是腹部肥胖和心血管风险的指标；然而，其与肌肉减少症的关联仍未得到探索。本研究探讨LAP与肌肉减少症之间的关系，重点关注糖尿病在这种关联中的中介作用。
分析了1999年至2018年通过美国国家健康与营养检查调查（NHANES）收集的10065名成年人的横断面数据。使用多变量逻辑回归模型确定LAP与肌肉减少症之间的比值比（OR），并通过中介分析评估糖尿病对LAP相关肌肉减少症的中介作用。
本研究纳入了10065名年龄在20岁及以上的参与者队列，其中1153人被诊断为肌肉减少症。在完全调整模型中，LAP与肌肉减少症的患病率呈正相关（OR = 2.57，95%CI = 1.46 - 4.50，P < 0.001）。当LAP从连续变量转换为分类变量时，与最低LAP四分位数相比（OR = 4.70，95%CI = 1.81 - 12.16，P < 0.001），较高的LAP水平与肌肉减少症患病率增加相关。受限立方样条分析显示LAP与肌肉减少症患病率之间存在曲线关系，在LAP = 4时存在显著拐点。亚组分析和敏感性分析证实了LAP与肌肉减少症之间的一致关联。此外，糖尿病被确定为这种关联中的部分中介因素，中介比例为31.1%。
该研究揭示LAP水平升高与肌肉减少症患病率增加之间存在显著相关性，糖尿病被确定为这种关联中的中介因素。需要进一步研究以探究其潜在机制。
