Mikkelsen Kathleen, Stojanovska Lily, Prakash Monica, Apostolopoulos Vasso
Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, PO Box 14426, Melbourne, VIC 8001, Australia.
Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, PO Box 14426, Melbourne, VIC 8001, Australia.
Maturitas. 2017 Feb;96:58-71. doi: 10.1016/j.maturitas.2016.11.012. Epub 2016 Nov 19.
Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein.
越来越多的证据表明，神经系统和免疫系统之间存在多种相互作用，并且免疫系统在抑郁症的发病机制中起重要作用。促炎细胞因子（如白细胞介素-1、白细胞介素-6、肿瘤坏死因子-α）与抑郁症的神经生物学表现有关。免疫/细胞因子网络对大脑有强大影响。此外，维生素B缺乏与抑郁症有关。因此，深入了解在维生素B衍生物存在的情况下免疫细胞如何变化，可能有助于更好地理解免疫变化与抑郁症之间的关联，本文将对此进行讨论。
