维生素B在健康衰老和疾病中的作用。

Role of Vitamin B in Healthy Ageing and Disease.

作者信息

Mikkelsen Kathleen, Trapali Maria, Apostolopoulos Vasso

机构信息

Institute for Health and Sport, Victoria University, Werribee, VIC, Australia.

Laboratory of Chemistry and Biochemistry and Cosmetic Science, Department of Biomedical Medicine, University of West Attica, Egaleo, Attiki, Greece.

出版信息

Subcell Biochem. 2024;107:245-268. doi: 10.1007/978-3-031-66768-8_12.

DOI:10.1007/978-3-031-66768-8_12

PMID:39693028

Abstract

B vitamin complex consist of vitamins B1, B2, B5, B6, B9, B12 and is pivotal for overall health, influencing vital functions such as, energy metabolism, DNA maintenance, and healthy immune system. Inadequate B vitamin levels are associated with various health issues, including neurocognitive problems, immune imbalances, and inflammation. In ageing individuals, deficiencies in B vitamins increase the risk of cardiovascular ailments, stroke, cognitive disorders, neurodegeneration, mental health issues, and methylation-related disorders. These result primarily due to changes in glycation, mitochondria, and oxidative stress. Thus, ensuring optimal vitamin B levels in the ageing population may be beneficial in preventing such age-related diseases. In this chapter we discuss the extensive role of B vitamins in the ageing process.

摘要

复合维生素B由维生素B1、B2、B5、B6、B9、B12组成，对整体健康至关重要，影响能量代谢、DNA维持和健康免疫系统等重要功能。维生素B水平不足与各种健康问题相关，包括神经认知问题、免疫失衡和炎症。在老年人中，维生素B缺乏会增加患心血管疾病、中风、认知障碍、神经退行性变、心理健康问题和甲基化相关疾病的风险。这些主要是由于糖基化、线粒体和氧化应激的变化导致的。因此，确保老年人群中维生素B的最佳水平可能有助于预防此类与年龄相关的疾病。在本章中，我们将讨论维生素B在衰老过程中的广泛作用。