Creus-Cuadros Anna, Tresserra-Rimbau Anna, Quifer-Rada Paola, Martínez-González Miguel Angel, Corella Dolores, Salas-Salvadó Jordi, Fitó Montse, Estruch Ramon, Gómez-Gracia Enrique, Lapetra José, Arós Fernando, Fiol Miquel, Ros Emili, Serra-Majem Lluís, Pintó Xavier, Moreno Juan José, Ruiz-Canela Miguel, Sorli Jose Vicente, Basora Josep, Schröder Helmut, Lamuela-Raventós Rosa Maria
J Acad Nutr Diet. 2017 Apr;117(4):609-622.e1. doi: 10.1016/j.jand.2016.11.003. Epub 2016 Dec 29.
The study of dietary patterns is gaining interest. Although the health benefits of yogurt and lignans have been investigated separately, to our knowledge there are no studies on their associative effects.
The aim of this study was to evaluate a possible association between yogurt and lignans using biomarkers of cardiovascular disease risk in an elderly population.
We conducted a cross-sectional analysis of the association between baseline dietary information and cardiovascular risk parameters using food frequency questionnaires.
We enrolled 7,169 Spanish participants of the PREDIMED (Prevención con Dieta Mediterránea) study (elderly men and women at high cardiovascular risk) from June 2003 to June 2009.
Cardiovascular risk parameters, including cholesterol, triglycerides, glucose, body mass index, weight, waist circumference, and blood pressure were measured.
General linear models were used to assess the relationship between categorical variables (yogurt, total dairy intake, lignans, and yogurt plus lignans) and cardiovascular risk parameters.
The consumption of either yogurt or lignans seems to have beneficial effects on human health, but the consumption of both showed greater improvement in some cardiovascular health parameters. Indeed, participants with a higher consumption of both yogurt and lignans showed lower total cholesterol (estimated β-coefficients=-6.18; P=0.001) and low-density lipoprotein cholesterol levels (β=-4.92; P=0.005). In contrast, participants with lower yogurt and lignan consumption had a higher body mass index (β=0.28; P=0.007) and weight (β=1.20; P=0.008).
High lignan and yogurt consumption is associated with a better cardiovascular risk parameters profile in an elderly Mediterranean population. Further research is warranted to determine the mechanisms and consequences of this potential effect.
饮食模式的研究越来越受到关注。尽管酸奶和木脂素对健康的益处已分别进行过研究，但据我们所知，尚无关于它们联合作用的研究。
本研究旨在通过老年人群心血管疾病风险生物标志物评估酸奶和木脂素之间可能存在的关联。
我们使用食物频率问卷对基线饮食信息与心血管风险参数之间的关联进行了横断面分析。
2003年6月至2009年6月，我们纳入了7169名参与PREDIMED（地中海饮食预防）研究的西班牙参与者（心血管疾病高风险的老年男性和女性）。
测量心血管风险参数，包括胆固醇、甘油三酯、血糖、体重指数、体重、腰围和血压。
使用一般线性模型评估分类变量（酸奶、总乳制品摄入量、木脂素以及酸奶加木脂素）与心血管风险参数之间的关系。
食用酸奶或木脂素似乎都对人体健康有益，但两者同时食用在某些心血管健康参数方面显示出更大改善。确实，酸奶和木脂素摄入量较高的参与者总胆固醇水平较低（估计β系数=-6.18；P=0.001），低密度脂蛋白胆固醇水平也较低（β=-4.92；P=0.005）。相比之下，酸奶和木脂素摄入量较低的参与者体重指数较高（β=0.28；P=0.007），体重也较高（β=1.20；P=0.008）。
在地中海老年人群中，高木脂素和酸奶摄入量与更好的心血管风险参数状况相关。有必要进一步研究以确定这种潜在作用的机制和后果。
