钌（II）亚胺配合物的光取代反应概述及其在光生物学和光动力疗法中的应用
An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy.
作者信息
White Jessica K, Schmehl Russell H, Turro Claudia
机构信息
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Department of Chemistry, Tulane University, New Orleans, LA 70118.
出版信息
Inorganica Chim Acta. 2017 Jan 1;454:7-20. doi: 10.1016/j.ica.2016.06.007. Epub 2016 Jun 18.
Abstract
This article is a short review that presents a short review of photosubstitution reactions of Ru(II) imine complexes and illustrates their use in the development of therapeutic agents. The review begins with an overview of the photophysical behavior and common photoreactions of Ru(II) imine complexes, with select examples from the literature since the 1960s. It is followed by a more detailed picture of the application of knowledge gained over the years in the development of Ru(II) complexes for photobiology and photodynamic therapy.
摘要
本文是一篇简短的综述，介绍了钌（II）亚胺配合物的光取代反应，并阐述了它们在治疗药物开发中的应用。综述首先概述了钌（II）亚胺配合物的光物理行为和常见的光化学反应，并列举了自20世纪60年代以来文献中的一些精选实例。随后更详细地介绍了多年来所积累的知识在钌（II）配合物用于光生物学和光动力治疗开发中的应用情况。
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2
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J Mater Chem B. 2016 Jan 21;4(3):394-408. doi: 10.1039/C5TB01613D. Epub 2015 Dec 1.
3
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Dalton Trans. 2016 Feb 21;45(7):2897-905. doi: 10.1039/c5dt03694a. Epub 2016 Jan 11.
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