Ma Xiaoxiao, Ouyang Zheng
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47906.
Trends Analyt Chem. 2016 Dec;85(A):10-19. doi: 10.1016/j.trac.2016.04.009.
Ambien ionization and miniaturization of mass spectrometers are two fields in mass spectrometry that have advanced significantly in the last decade. The integration of the techniques developed in these two fields is leading to the development of complete miniature analytical systems that can be used for on-site or point-of-care analysis by non-expert users. In this review, we report the current status of development in ambient ionization and miniature mass spectrometers, with an emphasis on those techniques with potential impact on the point-of-care (POC) diagnostics. The challenges in the future development of the integrated systems are discussed with possible solutions presented.
安比恩离子化和质谱仪的小型化是质谱分析领域中在过去十年取得显著进展的两个方面。这两个领域所开发技术的整合正推动着完整微型分析系统的发展，这些系统可供非专业用户用于现场或即时检测分析。在本综述中，我们报告了常压离子化和微型质谱仪的当前发展状况，重点关注那些对即时检测（POC）诊断有潜在影响的技术。我们还讨论了集成系统未来发展中的挑战，并提出了可能的解决方案。
