用于化学和生物分析的常压电离与微型质谱系统。
Ambient ionization and miniature mass spectrometry system for chemical and biological analysis.
作者信息
Ma Xiaoxiao, Ouyang Zheng
机构信息
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47906.
出版信息
Trends Analyt Chem. 2016 Dec;85(A):10-19. doi: 10.1016/j.trac.2016.04.009.
Abstract
Ambien ionization and miniaturization of mass spectrometers are two fields in mass spectrometry that have advanced significantly in the last decade. The integration of the techniques developed in these two fields is leading to the development of complete miniature analytical systems that can be used for on-site or point-of-care analysis by non-expert users. In this review, we report the current status of development in ambient ionization and miniature mass spectrometers, with an emphasis on those techniques with potential impact on the point-of-care (POC) diagnostics. The challenges in the future development of the integrated systems are discussed with possible solutions presented.
摘要
安比恩离子化和质谱仪的小型化是质谱分析领域中在过去十年取得显著进展的两个方面。这两个领域所开发技术的整合正推动着完整微型分析系统的发展，这些系统可供非专业用户用于现场或即时检测分析。在本综述中，我们报告了常压离子化和微型质谱仪的当前发展状况，重点关注那些对即时检测（POC）诊断有潜在影响的技术。我们还讨论了集成系统未来发展中的挑战，并提出了可能的解决方案。
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本文引用的文献
1
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Chem Sci. 2015 Jan 1;6(1):397-401. doi: 10.1039/c4sc02436b. Epub 2014 Sep 9.
2
Direct identification of prohibited substances in cosmetics and foodstuffs using ambient ionization on a miniature mass spectrometry system.使用微型质谱系统上的常压电离对化妆品和食品中的违禁物质进行直接鉴定。
Anal Chim Acta. 2016 Mar 17;912:65-73. doi: 10.1016/j.aca.2016.01.031. Epub 2016 Jan 27.
3
Acceleration of reaction in charged microdroplets.带电微滴中反应的加速。
Q Rev Biophys. 2015 Nov;48(4):437-44. doi: 10.1017/S0033583515000086.
4
Paper-capillary spray for direct mass spectrometry analysis of biofluid samples.用于生物流体样品直接质谱分析的纸质毛细管喷雾
Anal Bioanal Chem. 2016 Feb;408(5):1385-90. doi: 10.1007/s00216-015-9129-9. Epub 2015 Oct 31.
5
Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements.用于即时诊断和其他临床测量的常压电离质谱分析
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6
Real-time sample analysis using a sampling probe and miniature mass spectrometer.使用采样探头和微型质谱仪进行实时样本分析。
Anal Chem. 2015 Sep 1;87(17):8867-73. doi: 10.1021/acs.analchem.5b01943. Epub 2015 Aug 10.
7
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Anal Bioanal Chem. 2015 Sep;407(23):7229-38. doi: 10.1007/s00216-015-8887-8. Epub 2015 Jul 14.
8
Identification of fleeting electrochemical reaction intermediates using desorption electrospray ionization mass spectrometry.利用解吸电喷雾电离质谱鉴定瞬态电化学反应中间体。
J Am Chem Soc. 2015 Jun 17;137(23):7274-7. doi: 10.1021/jacs.5b03862. Epub 2015 Jun 2.
9
Reactive paper spray mass spectrometry for in situ identification of quinones.用于醌原位鉴定的反应性纸喷雾质谱法。
Rapid Commun Mass Spectrom. 2015 Jan 15;29(1):100-6. doi: 10.1002/rcm.7092.
10
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