表现为恶性软组织肿瘤的转移性脑膜瘤。
Metastatic meningioma presenting as a malignant soft tissue tumour.
作者信息
McCarthy Catherine, Hofer Monika, Vlychou Marianna, Khundkar Robar, Critchley Paul, Cudlip Simon, Ansorge Olaf, Athanasou Nick A
机构信息
Department of Radiology, Nuffield Orthopaedic Centre, Windmill Road, Oxford, OX3 7HE UK.
Department of Neuropathology, Oxford University Hospitals Oxford, Oxford, OX3 9DU UK.
出版信息
Clin Sarcoma Res. 2016 Dec 30;6:23. doi: 10.1186/s13569-016-0063-1. eCollection 2016.
BACKGROUND
Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.
CASE PRESENTATION
We report a case of a 58 year old man who presented with a mobile mass within the left trapezius muscle. The patient had previously undergone surgery for a right frontal lobe high grade anaplastic meningioma. Histology of the soft tissue lesion showed metastatic anaplastic meningioma with clumps of pleomorphic tumour cells which expressed epithelial membrane antigen, cytokeratin and P63 but were negative for other epithelial and mesenchymal markers. A PET-CT scan revealed additional metastatic lesions in the left pleura, liver and iliac bone.
CONCLUSIONS
Metastatic malignant meningioma can very rarely present as a high grade pleomorphic malignant soft tissue tumour and needs to be distinguished from soft tissue sarcomas and metastatic carcinomas that express epithelial antigens.
背景
恶性脑膜瘤颅外转移至软组织极为罕见，其临床、放射学及病理学特征尚不明确。
病例报告
我们报告一例58岁男性，其左斜方肌内出现一个可移动肿块。该患者曾因右额叶高级别间变性脑膜瘤接受手术。软组织病变的组织学检查显示为转移性间变性脑膜瘤，有成群的多形性肿瘤细胞，这些细胞表达上皮膜抗原、细胞角蛋白和P63，但其他上皮和间充质标志物呈阴性。PET-CT扫描显示左胸膜、肝脏和髂骨有额外的转移病灶。
结论
转移性恶性脑膜瘤极罕见地可表现为高级别多形性恶性软组织肿瘤，需要与表达上皮抗原的软组织肉瘤和转移性癌相鉴别。
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