• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

表现为恶性软组织肿瘤的转移性脑膜瘤。

Metastatic meningioma presenting as a malignant soft tissue tumour.

作者信息

McCarthy Catherine, Hofer Monika, Vlychou Marianna, Khundkar Robar, Critchley Paul, Cudlip Simon, Ansorge Olaf, Athanasou Nick A

机构信息

Department of Radiology, Nuffield Orthopaedic Centre, Windmill Road, Oxford, OX3 7HE UK.

Department of Neuropathology, Oxford University Hospitals Oxford, Oxford, OX3 9DU UK.

出版信息

Clin Sarcoma Res. 2016 Dec 30;6:23. doi: 10.1186/s13569-016-0063-1. eCollection 2016.

DOI:10.1186/s13569-016-0063-1
PMID:28042470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5200959/
Abstract

BACKGROUND

Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.

CASE PRESENTATION

We report a case of a 58 year old man who presented with a mobile mass within the left trapezius muscle. The patient had previously undergone surgery for a right frontal lobe high grade anaplastic meningioma. Histology of the soft tissue lesion showed metastatic anaplastic meningioma with clumps of pleomorphic tumour cells which expressed epithelial membrane antigen, cytokeratin and P63 but were negative for other epithelial and mesenchymal markers. A PET-CT scan revealed additional metastatic lesions in the left pleura, liver and iliac bone.

CONCLUSIONS

Metastatic malignant meningioma can very rarely present as a high grade pleomorphic malignant soft tissue tumour and needs to be distinguished from soft tissue sarcomas and metastatic carcinomas that express epithelial antigens.

摘要

背景

恶性脑膜瘤颅外转移至软组织极为罕见，其临床、放射学及病理学特征尚不明确。

病例报告

我们报告一例58岁男性，其左斜方肌内出现一个可移动肿块。该患者曾因右额叶高级别间变性脑膜瘤接受手术。软组织病变的组织学检查显示为转移性间变性脑膜瘤，有成群的多形性肿瘤细胞，这些细胞表达上皮膜抗原、细胞角蛋白和P63，但其他上皮和间充质标志物呈阴性。PET-CT扫描显示左胸膜、肝脏和髂骨有额外的转移病灶。

结论

转移性恶性脑膜瘤极罕见地可表现为高级别多形性恶性软组织肿瘤，需要与表达上皮抗原的软组织肉瘤和转移性癌相鉴别。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/00f638fae676/13569_2016_63_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/972524814656/13569_2016_63_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/1a8097a4e75a/13569_2016_63_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/d1d6ac540120/13569_2016_63_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/44b0dc254c9e/13569_2016_63_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/b15073f77344/13569_2016_63_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/de2f73eaf141/13569_2016_63_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/00f638fae676/13569_2016_63_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/972524814656/13569_2016_63_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/1a8097a4e75a/13569_2016_63_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/d1d6ac540120/13569_2016_63_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/44b0dc254c9e/13569_2016_63_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/b15073f77344/13569_2016_63_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/de2f73eaf141/13569_2016_63_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2500/5200959/00f638fae676/13569_2016_63_Fig7_HTML.jpg

相似文献

1
Metastatic meningioma presenting as a malignant soft tissue tumour.表现为恶性软组织肿瘤的转移性脑膜瘤。
Clin Sarcoma Res. 2016 Dec 30;6:23. doi: 10.1186/s13569-016-0063-1. eCollection 2016.
2
Primary Extracranial Meningioma of Mastoid in a Patient With History of Skin Squamous Cell Carcinoma, Lung Adenocarcinoma and Prostatic Carcinoma.一名有皮肤鳞状细胞癌、肺腺癌和前列腺癌病史患者的乳突原发性颅外脑膜瘤
Anticancer Res. 2019 Jun;39(6):3197-3201. doi: 10.21873/anticanres.13458.
3
More advantages in detecting bone and soft tissue metastases from prostate cancer using F-PSMA PET/CT.使用F-PSMA PET/CT检测前列腺癌骨和软组织转移方面有更多优势。
Hell J Nucl Med. 2019 Jan-Apr;22(1):6-9. doi: 10.1967/s002449910952. Epub 2019 Mar 7.
4
Multiple extracranial metastases of atypical meningiomas.非典型脑膜瘤的多发颅外转移
J Korean Neurosurg Soc. 2009 Feb;45(2):107-11. doi: 10.3340/jkns.2009.45.2.107. Epub 2009 Feb 28.
5
Adrenal metastasis of anaplastic meningioma: report of a rare case.颅外型间变性脑膜瘤肾上腺转移：1 例罕见病例报告。
Folia Neuropathol. 2019;57(4):366-372. doi: 10.5114/fn.2019.91195.
6
Metastatic rhabdoid meningioma of the parotid - Mimicking primary salivary gland neoplasm.腮腺转移性横纹肌样脑膜瘤——酷似原发性涎腺肿瘤。
Int J Surg Case Rep. 2015;6C:104-6. doi: 10.1016/j.ijscr.2014.10.048. Epub 2014 Dec 3.
7
Intracranial collision tumor mimicking an octreotide-SPECT positive and FDG-PET negative meningioma.酷似奥曲肽单光子发射计算机断层扫描（SPECT）阳性且氟代脱氧葡萄糖正电子发射断层显像（FDG-PET）阴性脑膜瘤的颅内碰撞瘤
J Clin Neurosci. 2005 Aug;12(6):720-3. doi: 10.1016/j.jocn.2004.09.016.
8
Intracranial anaplastic meningioma presenting as a cutaneous lesion: a case report of a cutaneous meningioma.表现为皮肤病变的颅内间变性脑膜瘤：一例皮肤脑膜瘤病例报告
Dermatol Online J. 2012 Sep 15;18(9):6.
9
Pulmonary and pleural metastasis of intracranial anaplastic meningioma in a 3-year-old boy: A case report.一名3岁男孩颅内间变性脑膜瘤的肺和胸膜转移：病例报告
Mol Clin Oncol. 2017 Oct;7(4):633-636. doi: 10.3892/mco.2017.1375. Epub 2017 Aug 14.
10
Primary intraosseous meningioma: an osteosclerotic bone tumour mimicking malignancy.原发性骨内脑膜瘤：一种酷似恶性肿瘤的骨硬化性骨肿瘤。
Clin Sarcoma Res. 2016 Aug 14;6:14. doi: 10.1186/s13569-016-0054-2. eCollection 2016.

引用本文的文献

1
Deciphering extracranial metastasis in high-grade meningiomas: insights from a case study and literature review.解读高级别脑膜瘤的颅外转移：来自一例病例研究及文献综述的见解
Ann Med Surg (Lond). 2025 Jan 21;87(2):1017-1023. doi: 10.1097/MS9.0000000000002948. eCollection 2025 Feb.
2
Metastatic meningioma: a case series and systematic review.转移性脑膜瘤：病例系列和系统评价。
Acta Neurochir (Wien). 2023 Oct;165(10):2873-2883. doi: 10.1007/s00701-023-05687-3. Epub 2023 Jul 26.
3
Surgical management of a giant hepatic metastasis from a cranial meningioma 10 years after resection.

本文引用的文献

1
Genetic landscape of meningioma.脑膜瘤的基因图谱。
Brain Tumor Pathol. 2016 Oct;33(4):237-247. doi: 10.1007/s10014-016-0271-7. Epub 2016 Sep 13.
2
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.2016 年世界卫生组织中枢神经系统肿瘤分类：概述。
Acta Neuropathol. 2016 Jun;131(6):803-20. doi: 10.1007/s00401-016-1545-1. Epub 2016 May 9.
3
Diffusion-Weighted Imaging in Meningioma: Prediction of Tumor Grade and Association with Histopathological Parameters.脑膜瘤的扩散加权成像：肿瘤分级的预测及与组织病理学参数的关联
颅底脑膜瘤切除术后10年巨大肝转移瘤的外科治疗
J Surg Case Rep. 2023 May 3;2023(5):rjad238. doi: 10.1093/jscr/rjad238. eCollection 2023 May.
4
Extraaxial Cerebellopontine Angle Medulloblastoma with Multiple Intracranial Metastases in Adult: A Rare Case Report with a Review of Literature.成人颅外小脑桥脑角髓母细胞瘤伴多发颅内转移：1例罕见病例报告并文献复习
Asian J Neurosurg. 2020 Aug 28;15(3):695-698. doi: 10.4103/ajns.AJNS_120_20. eCollection 2020 Jul-Sep.
5
WHO Grade I Meningioma Metastasis to the Lung 26 Years after Initial Surgery: A Case Report and Literature Review.世界卫生组织I级脑膜瘤初次手术后26年发生肺转移：1例病例报告及文献综述
NMC Case Rep J. 2019 Sep 12;6(4):125-129. doi: 10.2176/nmccrj.cr.2019-0020. eCollection 2019 Oct.
Transl Oncol. 2015 Dec;8(6):517-23. doi: 10.1016/j.tranon.2015.11.012.
4
Preoperative radiologic classification of convexity meningioma to predict the survival and aggressive meningioma behavior.凸面脑膜瘤的术前影像学分类以预测生存率及侵袭性脑膜瘤行为。
PLoS One. 2015 Mar 18;10(3):e0118908. doi: 10.1371/journal.pone.0118908. eCollection 2015.
5
Metastatic meningiomas: an unusual clinical and pathological diagnosis with highly variable outcome.转移性脑膜瘤：一种临床和病理诊断不常见且预后差异极大的疾病。
J Neurooncol. 2014 Nov;120(2):411-21. doi: 10.1007/s11060-014-1567-2. Epub 2014 Aug 1.
6
Distant metastases in meningioma: an underestimated problem.脑膜瘤的远处转移：一个被低估的问题。
J Neurooncol. 2013 May;112(3):323-7. doi: 10.1007/s11060-013-1074-x. Epub 2013 Feb 13.
7
Soft tissue metastases in lung cancer: a review of the literature.肺癌软组织转移：文献回顾。
Eur Rev Med Pharmacol Sci. 2012 Dec;16(14):1908-14.
8
Metastatic meningioma: The role of whole‑body diffusion-weighted imaging.转移性脑膜瘤：全身弥散加权成像的作用
Oncol Lett. 2011 Sep 1;2(5):931-933. doi: 10.3892/ol.2011.329. Epub 2011 Jun 24.
9
Atypical primary meningioma in the nasal septum with malignant transformation and distant metastasis.鼻中隔非典型性脑膜瘤伴恶性转化及远处转移。
BMC Cancer. 2012 Jul 3;12:275. doi: 10.1186/1471-2407-12-275.
10
Correlating apparent diffusion coefficients with histopathologic findings on meningiomas.探讨脑膜瘤表观弥散系数与组织病理学表现的相关性。
Eur J Radiol. 2012 Dec;81(12):4050-6. doi: 10.1016/j.ejrad.2012.06.002. Epub 2012 Jun 22.