Al-Zahrani Mohammad S, Abozor Basel M, Zawawi Khalid H
Department of Periodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2017 Jan;38(1):36-40. doi: 10.15537/smj.2017.1.16052.
To investigate the relationship between the presence of periapical lesions (PL) and levels of glycosylated hemoglobin (HbA1c), and C-reactive protein (CRP) in patients with type 2 diabetes. Methods: This cross-sectional study was conducted at Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia, between September 2013 and February 2015. Medical and dental history and Sociodemographic data were obtained from participants. Dental and periodontal examinations were conducted and blood samples were obtained to determine levels of HbA1c and CRP. The presence of PL was recorded from panoramic and periapical radiographs. Descriptive statistics and multivariable linear and logistic regression models were used for data analyses. Results: One hundred patients were included; mean age was 48.9 ± 8.5 years. Of these patients, 14% had no PL, whereas 25% had one or 2 lesions, 32% had 3 or 4 lesions, and 29% had ≥5 PL. The mean HbA1c was 9.8% (± 2.5) mg/L and CRP was 6.9 mg/L (± 6.3). The presence of PL was significantly associated with a higher level of HbA1c independent of age, gender, probing depth, and plaque index (p=0.023). Individuals with PL were also more likely to have a high CRP level (greater than 3 mg/L) independent of the previous covariates (odds ratio: 1.19; 95% confidence interval: 1.01-1.41). Conclusion: Periapical lesions are associated with a poorer glycemic control and a higher CRP level in type 2 diabetic patients.
探讨2型糖尿病患者根尖周病变（PL）的存在与糖化血红蛋白（HbA1c）及C反应蛋白（CRP）水平之间的关系。方法：本横断面研究于2013年9月至2015年2月在沙特阿拉伯王国吉达市的伊本·西那国立医学研究学院进行。从参与者处获取医学和牙科病史以及社会人口统计学数据。进行牙科和牙周检查，并采集血样以测定HbA1c和CRP水平。从全景片和根尖片记录PL的存在情况。采用描述性统计以及多变量线性和逻辑回归模型进行数据分析。结果：纳入100例患者；平均年龄为48.9±8.5岁。在这些患者中，14%无PL，而25%有1个或2个病变，32%有3个或4个病变，29%有≥5个PL。平均HbA1c为9.8%（±2.5）mg/L，CRP为6.9 mg/L（±6.3）。PL的存在与较高的HbA1c水平显著相关，且独立于年龄、性别、探诊深度和菌斑指数（p = 0.023）。有PL的个体也更有可能具有较高的CRP水平（大于3 mg/L），且独立于先前的协变量（比值比：1.19；95%置信区间：1.01 - 1.41）。结论：根尖周病变与2型糖尿病患者较差的血糖控制及较高的CRP水平相关。
