Sánchez-Domínguez Benito, López-López José, Jané-Salas Enric, Castellanos-Cosano Lizett, Velasco-Ortega Eugenio, Segura-Egea Juan José
Department of Stomatology, School of Dentistry, University of Sevilla, Sevilla, Spain.
Department of Odonto-stomatology, School of Dentistry, University of Barcelona, Barcelona, Spain.
J Endod. 2015 May;41(5):601-6. doi: 10.1016/j.joen.2014.12.024. Epub 2015 Feb 7.
The purpose of this investigation was to study the possible association between the prevalence of apical periodontitis (AP) and the glycemic control of type 2 diabetic patients.
In a cross-sectional study, the radiographic records of 83 type 2 diabetic patients were examined. Glycemic control was assessed by the mean glycated hemoglobin (HbA1c level). AP was diagnosed as radiolucent periapical lesions (RPLs) using the periapical index score. The Student t test, chi-square test, and logistic regression analysis were used in the statistical analysis.
Based on the HbA1c levels, 2 groups of diabetic patients were established: the HbA1c good control group (GCG, n = 24, HbA1c <6.5%) and the HbA1c poor control group (PCG, n = 59, HbA1c ≥6.5%). In the total sample, RPLs in 1 or more teeth were found in 62.7%, and no significant differences between GCG and PCG groups were observed (P = .13). At least 1 root-filled tooth was found in 32.5% of diabetic patients; this percentage was comparable in both HbA1c groups (P = .68). The prevalence of RPLs in RFT (29.6%) was similar in the GCG compared with the PCG (P = .94). Multivariate logistic regression analysis showed that worse periapical status correlated significantly with HbA1c levels ≥6.5% in type 2 diabetic patients (odd ratio = 3.8; 95% confidence interval, 1.1-13.0; P = .03).
HbA1c levels of diabetic patients are associated with periapical status. Data reported in the present study, together with the results of previous studies, further support a relationship between glycemic control and periapical inflammation in diabetic patients.
本研究的目的是探讨2型糖尿病患者根尖周炎（AP）患病率与血糖控制之间的可能关联。
在一项横断面研究中，检查了83例2型糖尿病患者的影像学记录。通过平均糖化血红蛋白（HbA1c水平）评估血糖控制情况。使用根尖指数评分将AP诊断为根尖周透射性病变（RPLs）。统计分析采用Student t检验、卡方检验和逻辑回归分析。
根据HbA1c水平，将糖尿病患者分为2组：HbA1c良好控制组（GCG，n = 24，HbA1c <6.5%）和HbA1c控制不佳组（PCG，n = 59，HbA1c≥6.5%）。在总样本中，62.7%的患者1颗或多颗牙齿存在RPLs，GCG组和PCG组之间未观察到显著差异（P = 0.13）。32.5%的糖尿病患者至少有1颗根管充填牙；这一比例在两个HbA1c组中相当（P = 0.68）。GCG组中RFT的RPLs患病率（29.6%）与PCG组相似（P = 0.94）。多因素逻辑回归分析显示，2型糖尿病患者根尖周状况较差与HbA1c水平≥6.5%显著相关（比值比 = 3.8；95%置信区间，1.1 - 13.0；P = 0.03）。
糖尿病患者的HbA1c水平与根尖周状况相关。本研究报告的数据以及先前研究的结果进一步支持了糖尿病患者血糖控制与根尖周炎症之间的关系。
