基于结构的药物设计方法在神经紊乱中的优势。
Advantages of Structure-Based Drug Design Approaches in Neurological Disorders.
机构信息
Computer Aided Drug Design and Molecular Modeling Lab, Department of Bioinformatics, Alagappa University, Karaikudi-630004, Tamil Nadu, India.
Department of Chemical Engineering, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Postal Code: 143-701, Seoul, Korea.
出版信息
Curr Neuropharmacol. 2017 Nov 14;15(8):1136-1155. doi: 10.2174/1570159X15666170102145257.
OBJECTIVE
The purpose of the review is to portray the theoretical concept on neurological disorders from research data.
BACKGROUND
The freak changes in chemical response of nerve impulse causes neurological disorders. The research evidence of the effort done in the older history suggests that the biological drug targets and their effective feature with responsive drugs could be valuable in promoting the future development of health statistics structure for improved treatment for curing the nervous disorders.
METHODS
In this review, we summarized the most iterative theoretical concept of structure based drug design approaches in various neurological disorders to unfathomable understanding of reported information for future drug design and development.
RESULTS
On the premise of reported information we analyzed the model of theoretical drug designing process for understanding the mechanism and pathology of the neurological diseases which covers the development of potentially effective inhibitors against the biological drug targets. Finally, it also suggests the management and implementation of the current treatment in improving the human health system behaviors.
CONCLUSION
With the survey of reported information we concluded the development strategies of diagnosis and treatment against neurological diseases which leads to supportive progress in the drug discovery.
目的
本综述旨在从研究数据中描绘神经紊乱的理论概念。
背景
神经冲动的化学反应异常会导致神经紊乱。对历史上早期研究成果的研究证据表明，生物药物靶点及其有效特征与反应性药物相结合，可能有助于促进未来健康统计结构的发展，从而改善治疗神经紊乱的效果。
方法
在本综述中，我们总结了基于结构的药物设计方法在各种神经紊乱中的最迭代理论概念，以深入了解报告信息，为未来的药物设计和开发提供参考。
结果
在报告信息的前提下，我们分析了理论药物设计过程的模型，以理解神经疾病的机制和病理学，涵盖了针对生物药物靶点的潜在有效抑制剂的开发。最后，它还提出了当前治疗方法的管理和实施，以改善人类健康系统行为。
结论
通过对报告信息的调查，我们总结了针对神经疾病的诊断和治疗的发展策略，这将有助于药物发现的支持性进展。
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