Baĭbekova E M, Sultanova L I
Biull Eksp Biol Med. 1989 Jul;108(7):109-12.
Utilization of general morphological, histochemical, morphometric and electron microscopic methods revealed marked structural changes of the liver in experimental chronic hepatitis and its subsequent correction with benzonal. The drug administration results in reversibility of the process due to significant action of cellular, and especially intracellular regenerative processes. The latter is supported by the presence of 2 types of cells, the 1st of which are characterized by predominant mitochondrial hypertrophy and hyperplasia suggesting increase in hepatocyte energy activity and the 2nd ones by hypertrophy of the elements of the smooth reticulum responsible for metabolism of foreign body substances being typical for the action of inductors of hepatic microsomal enzymes.
运用一般形态学、组织化学、形态计量学和电子显微镜方法揭示了实验性慢性肝炎时肝脏的显著结构变化以及随后用苯佐那尔对其进行的纠正。药物给药导致该过程的可逆性，这归因于细胞尤其是细胞内再生过程的显著作用。这一点得到两种类型细胞的存在的支持，第一种细胞的特征是主要线粒体肥大和增生，提示肝细胞能量活动增加，第二种细胞的特征是负责异物物质代谢的滑面内质网成分肥大，这是肝微粒体酶诱导剂作用的典型表现。
