Meerson F Z, Manukhina E B, Lapshin A V, Ustinova E E
Biull Eksp Biol Med. 1989 Jul;108(7):21-4.
The effect of experimental myocardial infarction on endothelium-dependent relaxation was studied on isolated rat aorta and compared with the dynamics of arterial pressure (AP). It was shown that the endothelium-dependent relaxation of aorta was increased 1.8 times 3 h following the myocardial infarction. Simultaneously the drop in AP which had begun immediately following the experimental infarction became maximal. In 24 h both the indices were restored practically to the initial level. There was a significant negative correlation between the extent of endothelium-dependent relaxation and AP. It was suggested that the increase in endothelium-dependent relaxation could influence vascular tone, the drop in AP, and, finally, the development of cardiogenic shock in myocardial infarction in man.
在离体大鼠主动脉上研究了实验性心肌梗死对内皮依赖性舒张的影响，并与动脉血压（AP）的动态变化进行了比较。结果表明，心肌梗死后3小时，主动脉的内皮依赖性舒张增加了1.8倍。同时，实验性梗死后立即开始的AP下降达到最大值。24小时后，这两个指标实际上都恢复到了初始水平。内皮依赖性舒张程度与AP之间存在显著的负相关。有人认为，内皮依赖性舒张的增加可能会影响血管张力、AP下降，最终影响人类心肌梗死中的心源性休克的发展。
