Nisihara Renato, Skare Thelma L, Zeni João Otávio, Rasera Henrique, Lidani Karita, Messias-Reason Iara
a Department of Medicine , Positivo University , Curitiba , Paraná , Brazil.
b Immunopathology Molecular Laboratory, Clinical Hospital , Federal University of Paraná , Curitiba , Paraná , Brazil.
Biomarkers. 2018 Feb;23(1):14-17. doi: 10.1080/1354750X.2016.1278265. Epub 2017 Jan 17.
Determining the disease's inflammatory activity in spondyloarthritis (SpA) is difficult although very important as it is this that drives treatment.
To investigate if plasma pentraxin-3 (PTX3) could act as an inflammatory marker in SpA.
Eighty one SpA patients (11 with psoriatic arthritis (PsoA) and 70 with ankylosing spondylitis (AS)) and 90 gender and age paired controls were studied for plasma PTX3 levels by ELISA. Patients had determinations of disease activity through C reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP. Epidemiological, clinical and treatment data were collected through chart review.
SpA patients had lower concentrations of plasma PTX3 than controls (median of 0.95 ng/mL vs 1.64 ng/mL; p < 0.0001). Correlation of PTX3 levels and BASDAI, ASDAS-CPR, CRP levels and ESR could not be found. No differences in PTX3 levels were detected between PSoA and AS patients (p = 0.42). Uveitis, presence of HLA B27, tobacco exposure, age and disease duration did not influence PTX3 levels.
PTX3 plasma levels do not reflect disease activity in SpA. However, it probably participates in the ethiopathogenetic process, as it is consumed in these patients.
虽然确定脊柱关节炎（SpA）的疾病炎症活动很困难，但却非常重要，因为正是炎症活动驱动着治疗。
研究血浆五聚体-3（PTX3）是否可作为SpA的炎症标志物。
采用酶联免疫吸附测定法（ELISA）研究81例SpA患者（11例银屑病关节炎（PsoA）患者和70例强直性脊柱炎（AS）患者）以及90例年龄和性别匹配的对照者的血浆PTX3水平。通过C反应蛋白（CRP）、红细胞沉降率（ESR）、巴斯强直性脊柱炎疾病活动指数（BASDAI）和强直性脊柱炎疾病活动评分（ASDAS）-CRP来测定患者的疾病活动情况。通过查阅病历收集流行病学、临床和治疗数据。
SpA患者的血浆PTX3浓度低于对照组（中位数分别为0.95 ng/mL和1.64 ng/mL；p < 0.0001）。未发现PTX3水平与BASDAI、ASDAS-CPR、CRP水平及ESR之间存在相关性。PsoA患者和AS患者的PTX3水平无差异（p = 0.42）。葡萄膜炎、HLA B27的存在、吸烟情况、年龄和病程均不影响PTX3水平。
血浆PTX3水平不能反映SpA的疾病活动情况。然而，它可能参与了发病机制过程，因为在这些患者中它被消耗。
