Gaziler Physical Therapy and Rehabilitation Training and Research Hospital, Clinic of Rheumatology, Ankara, Turkey.
Ankara City Hospital, Clinic of Rheumatology, Ankara, Turkey.
Int J Clin Pract. 2022 Mar 24;2022:7243399. doi: 10.1155/2022/7243399. eCollection 2022.
In clinical practice, it is hard to judge the level of disease activity in some patients with ankylosing spondylitis (AS) who have low traditional acute phase reactant values such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) but have considerable pain and inflammation. The aim of this study is to investigate plasma pentraxin 3 (PTX3) and serum amyloid P (SAP) levels in patients with AS who had normal ESR and CRP but high disease activity.
100 AS patients and 100 gender- and age-matched controls were included. Epidemiological, clinical, and treatment data and plasma levels of CRP, ESR, PTX3, and SAP were evaluated. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP were used for evaluating disease activity. Plasma levels of PTX3 and SAP were compared between AS patients and controls and also among AS patients with active and inactive disease.
AS patients had significantly higher plasma levels of PTX3 and SAP than controls. There were not any significant correlations between PTX3 and SAP with BASDAI, ASDAS-CRP, and ESR. There was a positive correlation between PTX3 and CRP. No significant difference in plasma levels of PTX3 and SAP was observed between patients with active disease and inactive disease, both with normal ESR and CRP levels. Disease duration and treatment did not influence plasma PTX3 levels.
In patients with AS, plasma levels of PTX3 and SAP were found to be elevated when compared to healthy controls. No association was observed between these biomarkers and disease activity.
在临床实践中，对于红细胞沉降率（ESR）和 C 反应蛋白（CRP）等传统急性期反应物值较低但疼痛和炎症明显的某些强直性脊柱炎（AS）患者，很难判断疾病活动度。本研究旨在探讨 ESR 和 CRP 正常但疾病活动度高的 AS 患者血浆五聚素 3（PTX3）和血清淀粉样蛋白 P（SAP）水平。
纳入 100 例 AS 患者和 100 名性别和年龄匹配的对照者。评估了流行病学、临床和治疗数据以及 CRP、ESR、PTX3 和 SAP 的血浆水平。采用 Bath 强直性脊柱炎疾病活动指数（BASDAI）和强直性脊柱炎疾病活动评分（ASDAS-CRP）评估疾病活动度。比较了 AS 患者与对照组及疾病活动期与非活动期 AS 患者的血浆 PTX3 和 SAP 水平。
AS 患者的血浆 PTX3 和 SAP 水平明显高于对照组。PTX3 和 SAP 与 BASDAI、ASDAS-CRP 和 ESR 之间均无显著相关性。PTX3 与 CRP 呈正相关。ESR 和 CRP 正常的活动期和非活动期 AS 患者的血浆 PTX3 和 SAP 水平无显著差异。疾病持续时间和治疗不影响血浆 PTX3 水平。
与健康对照者相比，AS 患者的血浆 PTX3 和 SAP 水平升高，但这些生物标志物与疾病活动度之间无关联。
