Xie Y, Chen B, Wang H, Wang K, Li R
Department of Burns, the Second Affiliated Hospital of Kunming Medical University, Burn Institute of Yunnan Province, Kunming 650101, China.
Zhonghua Shao Shang Za Zhi. 2016 Dec 20;32(12):762-764. doi: 10.3760/cma.j.issn.1009-2587.2016.12.013.
Mononuclear cell -derived multipotential cell (MOMC)is a unique cell population that derived from circulating CD14 mononuclear cell, with phenotypic characteristics of CD14 , CD45 , CD34 , as well as type Ⅰ collagen. It can be induced to differentiate into a wide range of mesenchymal lineages, including endothelium-like cells, myocardium-like cells, neuron-like cells, osteoid cells, chondroid cells, lipoid cells, myoid cells, epidermoid cells, and hepatoid cells. More strikingly, MOMC is easy to be obtained, and it can expand easily in vitro, which can be transplantated autologously without ethical limitations. MOMC is an ideal source of cell therapy for tissue regeneration and wound repair.
单核细胞衍生的多能细胞（MOMC）是一种独特的细胞群体，它源自循环中的CD14单核细胞，具有CD14、CD45、CD34以及Ⅰ型胶原蛋白的表型特征。它可以被诱导分化为多种间充质谱系细胞，包括内皮样细胞、心肌样细胞、神经样细胞、类骨细胞、类软骨细胞、类脂细胞、肌样细胞、表皮样细胞和肝样细胞。更引人注目的是，MOMC易于获取，并且能够在体外轻松扩增，可进行自体移植且不受伦理限制。MOMC是用于组织再生和伤口修复的细胞治疗的理想细胞来源。
