Seta Noriyuki, Kuwana Masataka
Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Keio J Med. 2007 Jun;56(2):41-7. doi: 10.2302/kjm.56.41.
Circulating monocytes are believed to be committed precursors for phagocytes, such as macrophages and dendritic cells. Recently, we have reported a primitive human cell population called monocyte-derived multipotential cells (MOMC), which has a fibroblast-like morphology and a unique phenotype positive for CD14, CD45, CD34, and type I collagen. This novel cell type exhibits mixed morphologic and phenotypic features of monocytes, endothelial cells, and mesenchymal cells. MOMC are derived from circulating CD14+ monocytes, and their differentiation requires binding to fibronectin and exposure to one or more soluble factors derived from peripheral blood CD14- cells. MOMC contain progenitors with capacity to differentiate into a variety of non-phagocytes, including bone, cartilage, fat, skeletal and cardiac muscle, neuron, and endothelium. Recent studies by others have also described several distinct human cell populations that are originated from circulating monocytes and have capacity to differentiate into non-phagocytes. These observations together indicate that circulating monocytes are more multipotential than previously thought. In addition, cell transplantation therapies using circulating monocytes are a potential approach for tissue regeneration.
循环单核细胞被认为是吞噬细胞（如巨噬细胞和树突状细胞）的定向前体细胞。最近，我们报道了一种原始的人类细胞群体，称为单核细胞衍生的多能细胞（MOMC），其具有成纤维细胞样形态，并且对CD14、CD45、CD34和I型胶原呈独特的表型阳性。这种新型细胞类型表现出单核细胞、内皮细胞和间充质细胞的混合形态和表型特征。MOMC来源于循环CD14 +单核细胞，其分化需要与纤连蛋白结合并暴露于源自外周血CD14 -细胞的一种或多种可溶性因子。MOMC含有能够分化为多种非吞噬细胞的祖细胞，包括骨、软骨、脂肪、骨骼肌和心肌、神经元和内皮细胞。其他人最近的研究也描述了几种不同的人类细胞群体，它们起源于循环单核细胞，并且有能力分化为非吞噬细胞。这些观察结果共同表明，循环单核细胞比以前认为的具有更多的多能性。此外，使用循环单核细胞的细胞移植疗法是组织再生的一种潜在方法。
