VanderMolen L A, Urba W J, Longo D L, Lawrence J, Gralnick H, Steis R G
Biological Response Modifiers Program, National Cancer Institute, Frederick, MD 21701.
Blood. 1989 Nov 1;74(6):2066-9.
We describe two patients with a new clinical pathologic syndrome of diffuse osteosclerosis in association with hairy cell leukemia. In both patients bone marrow biopsies could not be obtained due to extremely hard bones and inability to insert the biopsy needle; neither patient had a history of bony pain or fracture. The osteosclerotic process in one patient stabilized after successful treatment of her hairy cell leukemia with interferon alpha and deoxycoformycin suggesting that the osteosclerosis observed was related to the underlying malignant disease. Possible etiologic mechanisms are discussed.
我们描述了两名患有弥漫性骨硬化症与毛细胞白血病相关的新临床病理综合征的患者。由于骨头极其坚硬且无法插入活检针，两名患者均未能获得骨髓活检样本；两名患者均无骨痛或骨折病史。其中一名患者在使用干扰素α和脱氧助间型霉素成功治疗毛细胞白血病后，骨硬化过程得以稳定，这表明观察到的骨硬化与潜在的恶性疾病有关。文中讨论了可能的病因机制。
