Azami M, Sayehmiri K, YektaKooshali M H, HafeziAhmadi M R
Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
Department of Biostatistics, Research Center for Prevention of Psychosocial Impairment, Ilam University of Medical Sciences, Ilam, Iran.
Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S199-S200. doi: 10.1016/j.ijmyco.2016.11.022. Epub 2016 Nov 27.
Age increasing is caused physiological changes in the human body, such as reducing the power of the immune system. Weakened immune systems are more susceptible to bacterial infections like tuberculosis. So, this present study was performed for evaluating the prevalence of tuberculosis among Iranian elderly patients admitted to the infectious ward of a hospital.
This systematic review and meta-analysis study has been done based on PRISMA guidelines. A comprehensive search was conducted in Iranian and International databases included: Magiran, Iranmedex, IranDoc, SID, Medlib, Scopus, PubMed, Science Direct, Cochrane, Web of Science, Springer, Wiley Online Library as well as the Google Scholar search engine in the period 1990-2016 by two independent researchers using the Mesh keywords. All of the reviewed studies that had inclusion criterion were been evaluated. The diagnosis of tuberculosis were considered results of physical examination, PPD (Purified Protein Derivative) test, Blood tests, Imaging tests and sputum test. The data were analyzed by using random effects model with the software Stata-Ver.11.1.
Five studies with a total number of 2,956 elderly patients were included. The prevalence of tuberculosis among Iranian elderly patients admitted to the infectious ward of the hospital was estimated to be 15% (95%CI: 1-30). The relationship between prevalence of tuberculosis with a year of study was not statistically significant (P=0.371).
This will be the first systematic review of tuberculosis prevalence among elderly patients admitted to the infectious ward in Iran. This study showed a high prevalence of Tuberculosis and it is recommended considering tuberculosis as a differential diagnosis in elderly patients with infectious symptoms.
年龄增长会导致人体生理变化，比如免疫系统功能下降。免疫系统功能减弱更容易感染诸如肺结核之类的细菌感染。因此，本研究旨在评估入住某医院感染科病房的伊朗老年患者中结核病的患病率。
本系统评价和荟萃分析研究是根据PRISMA指南进行的。由两名独立研究人员使用医学主题词（Mesh）关键词，在1990年至2016年期间对伊朗和国际数据库进行了全面检索，这些数据库包括：Magiran、Iranmedex、IranDoc、SID、Medlib、Scopus、PubMed、Science Direct、Cochrane、Web of Science、Springer、Wiley Online Library以及谷歌学术搜索引擎。对所有符合纳入标准的综述研究进行了评估。结核病的诊断依据体格检查、结核菌素纯蛋白衍生物（PPD）试验、血液检查、影像学检查和痰液检查结果。使用Stata-Ver.11.1软件通过随机效应模型对数据进行分析。
纳入了五项研究，共有2956名老年患者。入住该医院感染科病房的伊朗老年患者中结核病的患病率估计为15%（95%置信区间：1%-30%）。结核病患病率与研究年份之间的关系无统计学意义（P = 0.371）。
这将是对伊朗入住感染科病房老年患者结核病患病率的首次系统评价。本研究显示结核病患病率较高，建议将结核病作为有感染症状老年患者的鉴别诊断。
