Maruyama Katsuya, Tsuji Hiroshi, Nomiya Takuma, Katoh Hiroyuki, Ishikawa Hitoshi, Kamada Tadashi, Wakatsuki Masaru, Akakura Koichiro, Shimazaki Jun, Aoyama Hidefumi, Tsujii Hirohiko
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
Department of Radiology and Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
J Radiat Res. 2017 Mar 1;58(2):260-266. doi: 10.1093/jrr/rrw122.
The aim of this study was to prospectively assess 5-year health-related quality of life (HRQOL) of patients treated with carbon ion radiotherapy (C-ion RT) for clinically localized prostate cancer. A total of 417 patients received carbon ion radiotherapy at a total dose of 63-66 Gray-equivalents (GyE) in 20 fractions over 5 weeks, and neoadjuvant and adjuvant androgen deprivation therapy (ADT) were administered for intermediate and high-risk patients. A HRQOL assessment was performed at five time points (immediately before the initiation of C-ion RT, immediately after, and at 12, 36 and 60 months after completion of C-ion RT) using Functional Assessment of Cancer Therapy (FACT) questionnaires. FACT-G and FACT-P scores were significantly decreased; however, the absolute change after 60 months was minimal. The transient decreases in the Trial Outcome Index (TOI) score returned to their baseline levels. Use of ADT, presence of adverse events, and biochemical failure were related to lower scores. Scores of subdomains of FACT instruments indicated characteristic changes. The pattern of HRQOL change after C-ion RT was similar to that of other modalities. Further controlled studies focusing on a HRQOL in patients with prostate cancer are warranted.
本研究的目的是前瞻性评估接受碳离子放疗（C离子放疗）的临床局限性前列腺癌患者的5年健康相关生活质量（HRQOL）。共有417例患者在5周内分20次接受了总剂量为63 - 66格雷当量（GyE）的碳离子放疗，中高危患者接受了新辅助和辅助雄激素剥夺治疗（ADT）。使用癌症治疗功能评估（FACT）问卷在五个时间点（C离子放疗开始前、结束后立即、结束后12个月、36个月和60个月）进行HRQOL评估。FACT - G和FACT - P评分显著降低；然而，60个月后的绝对变化很小。试验结果指数（TOI）评分的短暂下降恢复到基线水平。ADT的使用、不良事件的存在和生化失败与较低的评分相关。FACT工具子领域的评分显示出特征性变化。C离子放疗后HRQOL变化模式与其他治疗方式相似。有必要针对前列腺癌患者的HRQOL开展进一步的对照研究。
