Peng Fei, Tu Yingfeng, Adhikari Ashish, Hintzen Jordi C J, Löwik Dennis W P M, Wilson Daniela A
Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
Chem Commun (Camb). 2017 Jan 17;53(6):1088-1091. doi: 10.1039/c6cc09169e.
A nanomotor based strategy for fast cellular entry and cargo delivery is presented. The concept focuses on integrating tat peptide, a basic domain of HIV-1 tat protein, with state of the art nanomotors which possess attractive autonomous properties, facilitating cellular penetration and uptake. The rapid cellular internalization process leads to higher delivery efficiency.
本文提出了一种基于纳米马达的快速细胞内吞和货物递送策略。该概念重点在于将HIV-1 tat蛋白的碱性结构域tat肽与具有吸引人的自主特性的先进纳米马达相结合，促进细胞穿透和摄取。快速的细胞内化过程导致更高的递送效率。
