Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore.
Adv Healthc Mater. 2018 Apr;7(8):e1701276. doi: 10.1002/adhm.201701276. Epub 2018 Jan 15.
Engineered polymer vesicles, termed as polymersomes, confer a flexibility to control their structure, properties, and functionality. Self-assembly of amphiphilic copolymers leads to vesicles consisting of a hydrophobic bilayer membrane and hydrophilic core, each of which is loaded with a wide array of small and large molecules of interests. As such, polymersomes are increasingly being studied as carriers of imaging probes and therapeutic drugs. Effective delivery of polymersomes necessitates careful design of polymersomes. Therefore, this review article discusses the design strategies of polymersomes developed for enhanced transport and efficacy of imaging probes and therapeutic drugs. In particular, the article focuses on overviewing technologies to regulate the size, structure, shape, surface activity, and stimuli- responsiveness of polymersomes and discussing the extent to which these properties and structure of polymersomes influence the efficacy of cargo molecules. Taken together with future considerations, this article will serve to improve the controllability of polymersome functions and accelerate the use of polymersomes in biomedical applications.
聚合物囊泡，称为聚合物囊泡，赋予了其控制结构、性质和功能的灵活性。两亲性共聚物的自组装导致了由疏水性双层膜和亲水性核组成的囊泡，其中每个囊泡都装载了广泛的小分子和大分子感兴趣的物质。因此，聚合物囊泡作为成像探针和治疗药物的载体越来越受到研究的关注。聚合物囊泡的有效递药需要对聚合物囊泡进行精心设计。因此，本文讨论了为增强成像探针和治疗药物的输送和疗效而开发的聚合物囊泡的设计策略。特别是，本文重点综述了调节聚合物囊泡大小、结构、形状、表面活性和刺激响应性的技术，并讨论了聚合物囊泡的这些性质和结构在多大程度上影响了货物分子的疗效。结合未来的考虑因素，本文将有助于提高聚合物囊泡功能的可控性，并加速聚合物囊泡在生物医学应用中的使用。
