Tavakoli Javad
Biomechanics and Implant Research Group, Medical Device Research Institute, School of Computer Science, Engineering and Mathematic, Flinders University, Adelaide, SA, Australia.
Med Biol Eng Comput. 2017 Aug;55(8):1483-1492. doi: 10.1007/s11517-016-1609-3. Epub 2017 Jan 2.
The annulus fibrosus (AF) swelling property, which is correlated with its rheological and viscoelastic properties, plays a significant role in disc nutrition and mechanical loading justification during daily activities as well as designing scaffolds for tissue engineering applications. The objective of this study was twofold: firstly to characterize the AF single lamella swelling kinetics in different regions and solutions at the temperature range of 35-40 °C and secondly to use the swelling results as a baseline to model (independent to swelling media and anatomic region) the AF single lamella swelling. It was found that the AF single lamella swelling kinetics (equilibrium swelling ratio and swelling rate) depends on anatomic region and swelling media; however, its trend for different swelling media (ionic and molecular solution) is similar and the majority of hydration occurs during first 20% of equilibrium swelling time (about 20 min). Change in swelling rate constant in circumferential direction depends on the solution type. It decreases from anterior to lateral regions for water, PBS and glucose solution and remains constant-or its change is negligible-from lateral to posterolateral regions. The effect of temperature (in the range of 35-40 °C) on swelling kinetics was seen to be negligible. It was also understood that it is possible to present a model (independent to swelling media type) to predict the swelling kinetics of posterior and posterolateral AF single lamella, as these locations are less sensitive to the swelling media.
纤维环（AF）的肿胀特性与其流变学和粘弹性特性相关，在日常活动中的椎间盘营养和机械负荷调节以及组织工程应用的支架设计中起着重要作用。本研究的目的有两个：一是表征AF单层在35-40°C温度范围内不同区域和溶液中的肿胀动力学，二是将肿胀结果作为基线来模拟（独立于肿胀介质和解剖区域）AF单层的肿胀。研究发现，AF单层的肿胀动力学（平衡肿胀率和肿胀速率）取决于解剖区域和肿胀介质；然而，其在不同肿胀介质（离子和分子溶液）中的趋势相似，且大部分水化发生在平衡肿胀时间的前20%（约20分钟）内。圆周方向上肿胀速率常数的变化取决于溶液类型。对于水、磷酸盐缓冲液（PBS）和葡萄糖溶液，其从前侧区域到外侧区域降低，而从外侧区域到后外侧区域保持恒定或其变化可忽略不计。温度（在35-40°C范围内）对肿胀动力学的影响可忽略不计。还了解到，有可能提出一个模型（独立于肿胀介质类型）来预测后外侧和后外侧AF单层的肿胀动力学，因为这些位置对肿胀介质不太敏感。
