Andreuccetti Gabriel, Leyton Vilma, Lemos Nikolas P, Miziara Ivan Dieb, Ye Yu, Takitane Juliana, Munoz Daniel Romero, Reingold Arthur L, Cherpitel Cheryl J, de Carvalho Heraclito Barbosa
University of São Paulo Medical School, São Paulo, Brazil.
Alcohol Research Group, Emeryville, CA, USA.
Addiction. 2017 Apr;112(4):596-603. doi: 10.1111/add.13688. Epub 2017 Jan 3.
Most studies reporting alcohol use among fatally injured victims are subject to bias, particularly those related to sample selection and to absence of injury context data. We developed a research method to estimate the prevalence of alcohol consumption and test correlates of alcohol use prior to fatal injuries.
DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study based on a probability sample of fatally injured adult victims (n = 365) autopsied in São Paulo, Brazil. Victims were sampled within systematically selected 8-hour sampling blocks, generating a representative sample of fatal injuries occurring during all hours of the day for each day of the week between June 2014 and December 2015.
The presence of alcohol and blood alcohol concentration (BAC) were the primary outcomes evaluated according to victims' socio-demographic, injury context data (type, day, time and injury place) and criminal history characteristics.
Alcohol was detected in 30.1% [95% confidence interval (CI) = 25.6-35.1)] of the victims, with a mean blood alcohol level (BAC) level of 0.11% w/v (95% CI = 0.09-0.13) among alcohol-positive cases. Black and mixed race victims presented a higher mean BAC than white victims (P = 0.03). Fewer than one in every six suicides tested positive for alcohol, while almost half of traffic-related casualties were alcohol-positive. Having suffered traffic-related injuries, particularly those involving vehicle crashes, and injuries occurring during weekends and at night were associated significantly with alcohol use before injury (P < 0.05).
Nearly one-third of fatal injuries in São Paulo between June 2014 and December 2015 were alcohol-related, with traffic accidents showing a greater association with alcohol use than other injuries. The sampling methodology tested here, including the possibility of adding injury context data to improve population-based estimates of alcohol use before fatal injury, appears to be a reliable and lower-cost strategy for avoiding biases common in death investigations.
大多数报告致命伤受害者饮酒情况的研究都存在偏差,尤其是在样本选择和缺乏受伤背景数据方面。我们开发了一种研究方法,以估计酒精消费的患病率,并测试致命伤前饮酒的相关因素。
设计、地点与参与者:基于巴西圣保罗进行尸检的成年致命伤受害者(n = 365)概率样本的横断面研究。在系统选择的8小时采样时间段内对受害者进行采样,生成2014年6月至2015年12月期间每周每天全天发生的致命伤的代表性样本。
根据受害者的社会人口统计学、受伤背景数据(类型、日期、时间和受伤地点)以及犯罪史特征,评估酒精的存在和血液酒精浓度(BAC)作为主要结果。
在30.1% [95%置信区间(CI)= 25.6 - 35.1] 的受害者中检测到酒精,酒精阳性病例的平均血液酒精水平(BAC)为0.11% w/v(95% CI = 0.09 - 0.13)。黑人和混血种族受害者的平均BAC高于白人受害者(P = 0.03)。每六例自杀者中酒精检测呈阳性的不到一例,而近一半与交通相关的伤亡者酒精检测呈阳性。遭受与交通相关的伤害,特别是涉及车辆碰撞的伤害,以及在周末和夜间发生的伤害与受伤前饮酒显著相关(P < 0.05)。
2014年6月至2015年12月期间,圣保罗近三分之一的致命伤与酒精有关,交通事故与酒精使用的关联比其他伤害更大。这里测试的抽样方法,包括添加受伤背景数据以改进基于人群的致命伤前酒精使用估计的可能性,似乎是一种可靠且低成本的策略,可避免死亡调查中常见的偏差。