Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.
University of Science and Technology of China, Hefei 230026, People's Republic of China.
Sci Rep. 2017 Jan 3;7:39928. doi: 10.1038/srep39928.
This study reported an immediate approach for the degradation of three antibiotic (amoxicillin, ofloxacin, and cefradine) residues in medical intravenous infusion bottles (MIIBs) using high energy electron beam (HEEB) irradiation. The effects of irradiation doses, initial concentrations, initial pH, and scavengers of active radicals on the degradation of three antibiotic residues (ARs) were investigated, and the results displayed that 97.02%, 97.61% and 96.87% of amoxicillin, ofloxacin, and cefradine residues could be degraded in situ through HEEB irradiation respectively. Fourier transform infrared spectroscopy (FTIR) and high performance liquid chromatography-mass spectrometry (HPLC-MS) analysis demonstrated that ARs were mainly decomposed into inorganic ions and alkanes. Typically, the detailed degradation mechanism of ARs was also investigated, and the dominant active particle inducing the degradation of antibiotics during the HEEB irradiation process was demonstrated to be hydroxyl radical.
本研究报道了一种使用高能电子束（HEEB）辐照立即降解医用静脉输液瓶（MIIBs）中三种抗生素（阿莫西林、氧氟沙星和头孢菌素）残留的方法。考察了辐照剂量、初始浓度、初始 pH 值和活性自由基清除剂对三种抗生素残留（ARs）降解的影响，结果显示，通过 HEEB 辐照，阿莫西林、氧氟沙星和头孢菌素残留的去除率分别达到 97.02%、97.61%和 96.87%。傅里叶变换红外光谱（FTIR）和高效液相色谱-质谱（HPLC-MS）分析表明，ARs 主要分解为无机离子和烷烃。通常，还研究了 ARs 的详细降解机制，证明在 HEEB 辐照过程中诱导抗生素降解的主要活性粒子是羟基自由基。
