育亨宾对犬颌下腺唾液分泌的影响。
Effects of yohimbine on submaxillary salivation in dogs.
作者信息
Montastruc P, Berlan M, Montastruc J L
机构信息
Laboratoire de Pharmacologie Médicale et Clinique, Inserm U 317, Faculté de Médecine, Toulouse, France.
出版信息
Br J Pharmacol. 1989 Sep;98(1):101-4. doi: 10.1111/j.1476-5381.1989.tb16868.x.
Abstract
- The effects of yohimbine (0.5 mg kg-1 i.v.) on both resting and parasympathetic and sympathetic stimulation-induced submaxillary salivary responses were investigated in the anaesthetized dog. 2. Salivary secretion was increased significantly for a period of 45 min following an injection of yohimbine. 3. Sectioning of the chorda tympani (but not the cervical sympathetic) nerve abolished the yohimbine-induced increase in resting salivary secretion and potentiated that elicited by electrical stimulation of the chorda tympani nerve. 4. These results show that yohimbine increases submaxillary secretion by inhibition of presynaptic alpha 2-adrenoceptors located on the chorda tympani, which inhibit cholinergic transmission.
摘要
- 研究了育亨宾（0.5毫克/千克静脉注射）对麻醉犬静息状态以及副交感和交感神经刺激诱导的颌下唾液分泌反应的影响。2. 注射育亨宾后45分钟内，唾液分泌显著增加。3. 切断鼓索神经（而非颈交感神经）可消除育亨宾诱导的静息唾液分泌增加，并增强鼓索神经电刺激引起的唾液分泌。4. 这些结果表明，育亨宾通过抑制位于鼓索神经上的突触前α2-肾上腺素能受体来增加颌下腺分泌，该受体抑制胆碱能传递。
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