育亨宾的药代动力学研究及其对三环类抗抑郁药治疗患者唾液分泌的药效学作用。
Pharmacokinetic study of yohimbine and its pharmacodynamic effects on salivary secretion in patients treated with tricyclic antidepressants.
作者信息
Bagheri H, Picault P, Schmitt L, Houin G, Berlan M, Montastruc J L
机构信息
Laboratoire de Pharmacologie Médicale et Clinique, INSERUM U317, Faculté de Médecine, Toulouse, France.
出版信息
Br J Clin Pharmacol. 1994 Jan;37(1):93-6. doi: 10.1111/j.1365-2125.1994.tb04248.x.
The pharmacokinetic parameters and the time course of the effect after acute oral administration of yohimbine on salivary secretion in patients treated with tricyclic antidepressants were investigated. Yohimbine (10 mg) increased both salivary outflow and plasma noradrenaline levels for 4 h. Pharmacokinetic parameters (t1/2, tmax, Cmax and AUCexp) and plasma concentrations of noradrenaline were higher in patients treated with tricyclic antidepressants than in controls. At this dose, yohimbine induced a relatively large number of side effects. A lower dose (4 mg) increased salivary secretion for 3 h without any side effects in patients treated with tricyclic antidepressants but not in healthy volunteers. These data describe an interaction between yohimbine and tricyclic antidepressants and thus show that a relatively low dose (4 mg) of yohimbine could be useful in the treatment of dry mouth due to tricyclic antidepressants.
研究了急性口服育亨宾对接受三环类抗抑郁药治疗的患者唾液分泌的药代动力学参数及效应的时间过程。育亨宾（10毫克）使唾液流出量和血浆去甲肾上腺素水平在4小时内均升高。接受三环类抗抑郁药治疗的患者的药代动力学参数（t1/2、tmax、Cmax和AUCexp）以及去甲肾上腺素的血浆浓度高于对照组。在此剂量下，育亨宾引发了相对较多的副作用。较低剂量（4毫克）使接受三环类抗抑郁药治疗的患者唾液分泌增加3小时且无任何副作用，但对健康志愿者无效。这些数据描述了育亨宾与三环类抗抑郁药之间的相互作用，因此表明相对低剂量（4毫克）的育亨宾可能对治疗三环类抗抑郁药所致口干有用。
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