儿童肥胖中代谢性炎症的起始
The initiation of metabolic inflammation in childhood obesity.
作者信息
Singer Kanakadurga, Lumeng Carey N
出版信息
J Clin Invest. 2017 Jan 3;127(1):65-73. doi: 10.1172/JCI88882.
Abstract
An understanding of the events that initiate metabolic inflammation (metainflammation) can support the identification of targets for preventing metabolic disease and its negative effects on health. There is ample evidence demonstrating that the initiating events in obesity-induced inflammation start early in childhood. This has significant implications on our understanding of how early life events in childhood influence adult disease. In this Review we frame the initiating events of metainflammation in the context of child development and discuss what this reveals about the mechanisms by which this unique form of chronic inflammation is initiated and sustained into adulthood.
摘要
了解引发代谢性炎症（元炎症）的事件有助于确定预防代谢性疾病及其对健康负面影响的靶点。有充分证据表明，肥胖诱导炎症的起始事件在儿童早期就已开始。这对于我们理解儿童期早期生活事件如何影响成人疾病具有重要意义。在本综述中，我们将元炎症的起始事件置于儿童发育的背景下进行阐述，并讨论这揭示了这种独特形式的慢性炎症在成年期启动并持续的机制。
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