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从肺部分离出的细菌可调节小鼠的哮喘易感性。

Bacteria isolated from lung modulate asthma susceptibility in mice.

作者信息

Remot Aude, Descamps Delphyne, Noordine Marie-Louise, Boukadiri Abdelhak, Mathieu Elliot, Robert Véronique, Riffault Sabine, Lambrecht Bart, Langella Philippe, Hammad Hamida, Thomas Muriel

机构信息

Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

VIM, INRA, Université Paris-Saclay, Jouy-en-Josas, France.

出版信息

ISME J. 2017 May;11(5):1061-1074. doi: 10.1038/ismej.2016.181. Epub 2017 Jan 3.

DOI:10.1038/ismej.2016.181
PMID:28045458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5437918/
Abstract

Asthma is a chronic, non-curable, multifactorial disease with increasing incidence in industrial countries. This study evaluates the direct contribution of lung microbial components in allergic asthma in mice. Germ-Free and Specific-Pathogen-Free mice display similar susceptibilities to House Dust Mice-induced allergic asthma, indicating that the absence of bacteria confers no protection or increased risk to aeroallergens. In early life, allergic asthma changes the pattern of lung microbiota, and lung bacteria reciprocally modulate aeroallergen responsiveness. Primo-colonizing cultivable strains were screened for their immunoregulatory properties following their isolation from neonatal lungs. Intranasal inoculation of lung bacteria influenced the outcome of allergic asthma development: the strain CNCM I 4970 exacerbated some asthma features whereas the pro-Th1 strain CNCM I 4969 had protective effects. Thus, we confirm that appropriate bacterial lung stimuli during early life are critical for susceptibility to allergic asthma in young adults.

摘要

哮喘是一种慢性、不可治愈的多因素疾病，在工业化国家发病率不断上升。本研究评估了肺部微生物成分在小鼠过敏性哮喘中的直接作用。无菌小鼠和无特定病原体小鼠对屋尘螨诱导的过敏性哮喘表现出相似的易感性，这表明细菌的缺失对空气过敏原既没有保护作用也不会增加风险。在生命早期，过敏性哮喘会改变肺部微生物群的模式，而肺部细菌会相互调节对空气过敏原的反应性。从新生小鼠肺部分离出的初代定殖可培养菌株，对其免疫调节特性进行了筛选。经鼻接种肺部细菌会影响过敏性哮喘的发展结果：菌株CNCM I 4970会加剧某些哮喘特征，而促Th1菌株CNCM I 4969则具有保护作用。因此，我们证实生命早期适当的肺部细菌刺激对于年轻人过敏性哮喘的易感性至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/934f/5437918/14e986870c93/ismej2016181f8.jpg
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