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Statin Adjunctive Therapy for Tuberculosis Treatment.他汀类药物辅助治疗结核病
Antimicrob Agents Chemother. 2016 Oct 21;60(11):7004. doi: 10.1128/AAC.01836-16. Print 2016 Nov.
2
Statin adjunctive therapy shortens the duration of TB treatment in mice.他汀类辅助治疗可缩短小鼠结核病治疗疗程。
J Antimicrob Chemother. 2016 Jun;71(6):1570-7. doi: 10.1093/jac/dkw014. Epub 2016 Feb 21.
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Are There Sex-Specific Differences in Response to Adjunctive Host-Directed Therapies for Tuberculosis?针对结核病的辅助宿主导向疗法的反应是否存在性别差异？
Front Immunol. 2020 Jul 7;11:1465. doi: 10.3389/fimmu.2020.01465. eCollection 2020.
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Statins as Adjunctive Therapy Against Tuberculosis (TB): The Balance Between Statin-Induced Anti-TB Effect and Trained Immunity Suppression.他汀类药物作为结核病辅助治疗：他汀类药物诱导的抗结核作用与训练免疫抑制之间的平衡
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Statin therapy may prevent development of tuberculosis in diabetic state.他汀类药物治疗可能预防糖尿病状态下结核病的发生。
Med Hypotheses. 2014 Jul;83(1):88-91. doi: 10.1016/j.mehy.2014.04.002. Epub 2014 Apr 13.
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Reply to Hu et al: Could there be detrimental effects of statin adjunctive TB therapy on immune responses?回复胡等人：他汀类药物辅助结核病治疗会对免疫反应产生有害影响吗？
J Infect Dis. 2020 Jun 29;222(2):336-337. doi: 10.1093/infdis/jiz676.
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Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation.他汀类药物治疗通过增强自噬和吞噬体成熟来减少人类巨噬细胞和小鼠中的结核分枝杆菌负担。
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Statin therapy resolves coronary artery inflammation.他汀类药物治疗可消除冠状动脉炎症。
JACC Cardiovasc Imaging. 2013 Oct;6(10):1119-1120. doi: 10.1016/j.jcmg.2013.02.013.
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Statin therapy enhance benefit of exercise training in patients with claudication intermittens.
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Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial.在机会窗乳腺癌试验中用他汀类药物靶向 HMG-CoA 还原酶。
Breast Cancer Res Treat. 2013 Apr;138(2):499-508. doi: 10.1007/s10549-013-2473-6. Epub 2013 Mar 8.

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Immunomodulatory effects of atorvastatin on peripheral blood mononuclear cells infected with .阿托伐他汀对感染……的外周血单个核细胞的免疫调节作用 。 你提供的原文中“infected with”后面似乎缺失了具体内容。
Front Immunol. 2025 Jul 3;16:1597534. doi: 10.3389/fimmu.2025.1597534. eCollection 2025.
2
Integrative transcriptome-based drug repurposing in tuberculosis.基于整合转录组学的结核病药物再利用研究
bioRxiv. 2025 Jun 2:2025.06.02.657296. doi: 10.1101/2025.06.02.657296.
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Clinical, metabolic, and immune interaction between tuberculosis and diabetes mellitus: implications and opportunities for therapies.结核病与糖尿病之间的临床、代谢及免疫相互作用：治疗的意义与机遇
Expert Opin Pharmacother. 2025 May 26:1-14. doi: 10.1080/14656566.2025.2508904.
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Review of the Effectiveness of Various Adjuvant Therapies in Treating .各种辅助疗法在治疗……中的有效性综述
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Repurposing Immunomodulatory Drugs to Combat Tuberculosis.免疫调节药物再利用以对抗结核病。
Front Immunol. 2021 Apr 13;12:645485. doi: 10.3389/fimmu.2021.645485. eCollection 2021.
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Early cell-autonomous accumulation of neutral lipids during infection promotes mycobacterial growth.早期感染过程中中性脂质的细胞自主积累促进分枝杆菌生长。
PLoS One. 2020 May 14;15(5):e0232251. doi: 10.1371/journal.pone.0232251. eCollection 2020.
7
Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice.他汀类药物辅助宿主导向治疗可改善小鼠结核病相关结局。
J Infect Dis. 2020 Mar 16;221(7):1079-1087. doi: 10.1093/infdis/jiz517.
8
Association between Tuberculosis, Statin Use, and Diabetes: A Propensity Score-Matched Analysis.结核病、他汀类药物使用与糖尿病之间的关联：倾向评分匹配分析。
Am J Trop Med Hyg. 2019 Aug;101(2):350-356. doi: 10.4269/ajtmh.18-0983.

本文引用的文献

1
Is There Potential for Repurposing Statins as Novel Antimicrobials?他汀类药物能否被重新用作新型抗菌药物？
Antimicrob Agents Chemother. 2016 Aug 22;60(9):5111-21. doi: 10.1128/AAC.00192-16. Print 2016 Sep.
2
Statin adjunctive therapy shortens the duration of TB treatment in mice.他汀类辅助治疗可缩短小鼠结核病治疗疗程。
J Antimicrob Chemother. 2016 Jun;71(6):1570-7. doi: 10.1093/jac/dkw014. Epub 2016 Feb 21.
3
New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects.新型抗结核药物、方案和辅助治疗：需求、进展和未来前景。
Lancet Infect Dis. 2014 Apr;14(4):327-40. doi: 10.1016/S1473-3099(13)70328-1.
4
Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation.他汀类药物治疗通过增强自噬和吞噬体成熟来减少人类巨噬细胞和小鼠中的结核分枝杆菌负担。
J Infect Dis. 2014 Mar 1;209(5):754-63. doi: 10.1093/infdis/jit550. Epub 2013 Oct 16.
5
Adverse reactions due to directly observed treatment strategy therapy in Chinese tuberculosis patients: a prospective study.中国结核病患者直接观察治疗策略治疗的不良反应：一项前瞻性研究。
PLoS One. 2013 Jun 4;8(6):e65037. doi: 10.1371/journal.pone.0065037. Print 2013.
6
Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa.南非广泛耐药结核病患者接受治疗时与药物相关的不良事件及其与结局的关系。
PLoS One. 2013 May 7;8(5):e63057. doi: 10.1371/journal.pone.0063057. Print 2013.
7
Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrations.利福平可大幅降低血浆中辛伐他汀及辛伐他汀酸的浓度。
Clin Pharmacol Ther. 2000 Dec;68(6):592-7. doi: 10.1067/mcp.2000.111414.

Statin Adjunctive Therapy for Tuberculosis Treatment.

作者信息

Alffenaar Jan-Willem C, Akkerman Onno W, van Hest Rob

机构信息

University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands

University of Groningen, University Medical Center Groningen, Tuberculosis Center Beatrixoord, Haren, The Netherlands.

出版信息

Antimicrob Agents Chemother. 2016 Oct 21;60(11):7004. doi: 10.1128/AAC.01836-16. Print 2016 Nov.

DOI:10.1128/AAC.01836-16
PMID:28045667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5075134/
Abstract
摘要